For nearly 500 years, scholars have argued about the origin and antiquity of syphilis. Did
Columbus bring the disease from the New World to the Old World? Or did syphilis exist in the …

Simple Summary Here, we describe a previously unreported mechanism of PD-1/MET
interaction and PD-1 induction of epithelial-to-mesenchymal transition (EMT), which is observed …

Purpose We evaluated the consequences of cobalt–chromium alloy (CoCr) wear debris
challenge in the peri-spine region to determine the inflammation and toxicity associated with …

Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers with few
treatment options, necessitating an urgent need for novel therapeutics. Immuno-oncologic (IO) …

The biological effect of wear of articulating surfaces is a continued concern with large joint
replacements and, likewise, of interest for total disc replacements. There are a number of …

We describe a new conservation decision support tool: ‘Optimal Restoration of Altered Habitats’
(OPRAH). OPRAH combines species landscape configuration preferences and habitat …

Mechanosensitive mechanisms are often used to sense damage to tissue structure,
stimulating matrix synthesis and repair. While this kind of mechanoregulatory process is well …

Background: Most children who need emergency care visit general emergency departments
and urgent care centres; the weighted pediatric readiness score (WPRS) is currently used to …

Simple Summary Gastric cancer is a deadly disease with no established method to choose
the most effective chemotherapy for each patient. To address this public health issue, our …

Discussion: Presented is a rare case of chronic PVT in a patient with JAK2 mutation leading
to CTPV refractory to anticoagulation or endovascular intervention, eventually requiring MT. …