An emerging concept is that the mammalian myocardium has the potential to regenerate,
but that regeneration might be too inefficient to repair the extensive myocardial injury that is …

Background: The impact of gut microbiota on the regulation of host physiology has recently
garnered considerable attention, particularly in key areas such as the immune system and …

Endothelial cells can protect cardiomyocytes from injury, but the mechanism of this protection
is incompletely described. Here we demonstrate that protection of cardiomyocytes by …

Strategies for cardiac repair include injection of cells, but these approaches have been
hampered by poor cell engraftment, survival, and differentiation. To address these shortcomings …

Object A primary consideration of all spinal fusion procedures is restoration of normal anatomy,
including disc height, lumbar lordosis, foraminal decompression, and sagittal balance. …

Mammalian cardiomyocytes have limited proliferation potential, and acutely injured mammalian
hearts do not regenerate adequately. Instead, injured myocardium develops fibrosis and …

▪ Abstract Communication between endothelial cells and cardiomyocytes regulates not only
early cardiac development but also adult cardiomyocyte function, including the contractile …

Background— Local delivery methods can target therapies to specific tissues and potentially
avoid toxicity to other organs. Platelet-derived growth factor can protect the myocardium, …

Angiogenic therapy is a promising approach for tissue repair and regeneration. However,
recent clinical trials with protein delivery or gene therapy to promote angiogenesis have failed …

Many strategies for repairing injured myocardium are under active investigation, with some
early encouraging results. These strategies include cell therapies, despite little evidence of …