… Murine glioma tissue samples were provided by Pavan S. Upadhyayula and Liang Lei.
This research was supported by grants to BRS from the National Cancer Institute(R35CA209896 …

Although radiation is widely used to treat cancers, resistance mechanisms often develop
and involve activation of DNA repair and inhibition of apoptosis. Therefore, compounds that …

Only a subset of recurrent glioblastoma (rGBM) responds to anti-PD-1 immunotherapy.
Previously, we reported enrichment of BRAF/PTPN11 mutations in 30% of rGBM that responded …

Ferroptosis is mediated by lipid peroxidation of phospholipids containing polyunsaturated
fatty acyl moieties. Glutathione, the key cellular antioxidant capable of inhibiting lipid …

Background Macrophages are the most common infiltrating immune cells in gliomas and play
a wide variety of pro-tumor and anti-tumor roles. However, the different subpopulations of …

Traumatic spinal cord injury (SCI) often occurs in patients with concurrent traumatic injuries
in other body systems. These patients with polytrauma pose unique challenges to clinicians. …

Importance O 6 -methylguanine-DNA methyltransferase (MGMT[OMIM156569]) promoter
methylation (mMGMT) is predictive of response to alkylating chemotherapy for glioblastomas …

Background Topotecan is cytotoxic to glioma cells but is clinically ineffective because of drug
delivery limitations. Systemic delivery is limited by toxicity and insufficient brain penetrance, …

Purpose Glioblastoma (GBM) is a devastating disease. With the current treatment of surgery
followed by chemoradiation, outcomes remain poor, with median survival of only 15 months …

The prevalence of neuropsychiatric disorders following traumatic brain injury (TBI) is 20%–50%,
and disorders of mood and cognition may remain even after recovery of neurologic …