The proto-oncogene ROS1 encodes a receptor tyrosine kinase with an unknown physiological
role in humans. Somatic chromosomal fusions involving ROS1 produce chimeric …

ROS1 is the largest receptor tyrosine kinase in the human genome. Rearrangements of the
ROS1 gene result in oncogenic ROS1 kinase fusion proteins that are currently the only …

This study functionally characterizes MYC overexpression as a novel form of therapeutic
resistance to ROS1 tyrosine kinase inhibitors in non–small cell lung cancer and proposes …

Purpose: Gliomas, a genetically heterogeneous group of primary central nervous system
tumors, continue to pose a significant clinical challenge. Discovery of chromosomal …

Angiosarcomas are rare, malignant soft tissue tumors in children that arise in a wide range
of anatomical locations and have limited targeted therapies available. Here, we report a rare …

The emergence of pneumonia-like symptoms in late 2019 heralded the beginning of a global
health crisis, resulting in the COVID-19 pandemic. Following the identification of Severe …

Background: The deleterious effect of diabetes mellitus on surgical outcomes is well
documented for joint replacement surgery. We analyzed the large national US Department of …

The use of air quality monitoring networks to inform urban policies is critical especially
where urban populations are exposed to unprecedented levels of air pollution. High costs, …

Intradural spinal teratomas are rare tumors of the spinal cord that are infrequently encountered
in children. Although the mechanistic basis for the formation of these tumors is unclear, …

Background: Currently, 37% of adults in the United States are obese, and 34% are overweight.
Obesity poses a particularly complex challenge in spinal surgery management, whereby …