To induce bone regeneration there is a complex cascade of growth factors. Growth factors
such as recombinant BMP-2, BMP-7, and PDGF are FDA-approved therapies in bone …

In the last twenty years, due to an increasing medical and market demand for orthopaedic
implants, several grafting options have been developed. However, when alternative bone …

OBJECTIVE In 2021, several patients across the United States received bone allograft
contaminated with Mycobacterium tuberculosis (TB). TB is typically a pulmonary infection …

OBJECTIVE The use of allograft cellular bone matrices (ACBMs) in spinal fusion has
expanded rapidly over the last decade. Despite little objective data on its effectiveness …

Insufficient bone regeneration is a common issue for patients with extensive bone damage,
therefore the use of allografts is required. With increasing life expectancy, there is a higher …

Study Design: Narrative Review. Objectives: The increasing cost of healthcare overall and
for spine surgery, coupled with the growing burden of spine-related disease and rising …

BACKGROUND: Previous analyses of the US Food and Drug Administration (FDA)
Investigational Device Exemption study demonstrated the superiority of i-FACTOR …

Introduction: Interbody fusion devices are customarily used in fusion of the anterior spinal
column for treatment of degenerative disc disease. Their traditional role is to reestablish and …

When Shandra Eisenga underwent an elective spine surgery in April 2023, her hope was
that it would let her spend more quality time with her grandchildren. A 57-year-old resident of …

Study Design. Finite element analysis (FEA) and in vivo ovine spinal interbody fusion study.
Objective. To determine comparative load-induced strain amplitudes, bone mineralization …