Leptomeningeal disease has become increasingly prevalent as novel therapeutic interventions
extend the survival of cancer patients. Although a majority of leptomeningeal spread …

Objective The diagnosis and treatment of complex regional pain syndrome (CRPS) is
challenging and there is a paucity of data describing its overall cost burden and quantifying its …

The lack of effective treatments for autism spectrum disorder (ASD) and congenital
hydrocephalus (CH) reflects the limited understanding of the biology underlying these common …

T cell dysfunction contributes to tumor immune escape in patients with cancer and is
particularly severe amidst glioblastoma (GBM). Among other defects, T cell lymphopenia is …

Purpose: T-cell dysfunction is a hallmark of glioblastoma (GBM). Although anergy and
tolerance have been well characterized, T-cell exhaustion remains relatively unexplored. …

Study Design. Ambispective cohort review. Objective. To examine the effects of early mobilization
on patient outcomes, complications profile, and 30-day readmission rates. Summary of …

Adoptive transfer of T cells expressing chimeric antigen receptors (CARs) is an effective
immunotherapy for B-cell malignancies but has failed in some solid tumors clinically. …

Background/Objective There are limited data on the risks and benefits of using andexanet alfa
(AA) in comparison with four-factor prothrombin complex concentrate (4F-PCC) to reverse …

Background: Failed back surgery syndrome (FBSS) is a cause of significant morbidity for up
to 40% of patients following spine surgery, and is estimated to cost almost $20 billion. …

Background: Patients with pain conditions place significant demands on health care services
globally. Health economists have reported the annual economic cost of pain in the United …