[HTML][HTML] Crossing the blood-brain barrier: advances in nanoparticle technology for drug delivery in neuro-oncology
The blood-brain barrier (BBB) constitutes a microvascular network responsible for excluding
most drugs from the brain. Treatment of brain tumors is limited by the impermeability of the …
most drugs from the brain. Treatment of brain tumors is limited by the impermeability of the …
Patient-identified factors related to heart failure readmissions
Background— Although readmission after hospitalization for heart failure has received
increasing attention, little is known about its root causes. Prior investigations have relied on …
increasing attention, little is known about its root causes. Prior investigations have relied on …
[HTML][HTML] Applications of focused ultrasound for the treatment of glioblastoma: a new frontier
AM Hersh, M Bhimreddy, C Weber-Levine, K Jiang… - Cancers, 2022 - mdpi.com
Simple Summary Glioblastoma (GBM) is a common primary brain tumor with a short median
overall survival despite aggressive treatment with resection, chemotherapy, and radiation …
overall survival despite aggressive treatment with resection, chemotherapy, and radiation …
Perioperative outcomes and survival after surgery for intramedullary spinal cord tumors: a single-institution series of 302 patients
OBJECTIVE Intramedullary spinal cord tumors (IMSCTs) are rare neoplasms whose treatment
is often technically challenging. Given the low volume seen at most centers, perioperative …
is often technically challenging. Given the low volume seen at most centers, perioperative …
[HTML][HTML] Percentage of time in range 70 to 139 mg/dL is associated with reduced mortality among critically ill patients receiving IV insulin infusion
MJ Lanspa, JS Krinsley, AM Hersh, EL Wilson… - Chest, 2019 - Elsevier
Background In addition to hyperglycemia, hypoglycemia, and glycemic variability, reduced
time in targeted blood glucose range (TIR) is associated with increased risk of death in …
time in targeted blood glucose range (TIR) is associated with increased risk of death in …
[HTML][HTML] Empirical consequences of current recommendations for the design and interpretation of noninferiority trials
Background Noninferiority trials are increasingly common, though they have less
standardized designs and their interpretation is less familiar to clinicians than superiority trials. …
standardized designs and their interpretation is less familiar to clinicians than superiority trials. …
Augmented reality in spine surgery: a narrative review
Augmented reality (AR) navigation refers to novel technologies that superimpose images,
such as radiographs and navigation pathways, onto a view of the operative field. The …
such as radiographs and navigation pathways, onto a view of the operative field. The …
[HTML][HTML] Molecular pathways and genomic landscape of glioblastoma stem cells: opportunities for targeted therapy
Simple Summary Glioblastoma stem cells are a unique population of tumor cells that contribute
to tumor growth, invasion, and resistance to chemotherapy and radiation therapy. These …
to tumor growth, invasion, and resistance to chemotherapy and radiation therapy. These …
Comparison of frailty metrics and the Charlson Comorbidity Index for predicting adverse outcomes in patients undergoing surgery for spine metastases
OBJECTIVE Frailty—the state defined by decreased physiological reserve and increased
vulnerability to physiological stress—is exceedingly common in oncology patients. Given the …
vulnerability to physiological stress—is exceedingly common in oncology patients. Given the …
Low-intensity pulsed ultrasound neuromodulation of a rodent's spinal cord suppresses motor evoked potentials
…, T Awosika, M Kerensky, AM Hersh… - IEEE Transactions …, 2023 - ieeexplore.ieee.org
Objective: Here we investigate the ability of low-intensity ultrasound (LIUS) applied to the
spinal cord to modulate the transmission of motor signals. Methods: Male adult Sprague-…
spinal cord to modulate the transmission of motor signals. Methods: Male adult Sprague-…
