User profiles for Bradley Gelfand
 | Bradley D GelfandUniversity of Virginia Verified email at virginia.edu Cited by 4201 |
DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration
Geographic atrophy (GA), an untreatable advanced form of age-related macular degeneration,
results from retinal pigmented epithelium (RPE) cell degeneration. Here we show that the …
results from retinal pigmented epithelium (RPE) cell degeneration. Here we show that the …
Immunology of age-related macular degeneration
J Ambati, JP Atkinson, BD Gelfand - Nature Reviews Immunology, 2013 - nature.com
Age-related macular degeneration (AMD) is a leading cause of blindness in aged
individuals. Recent advances have highlighted the essential role of immune processes in the …
individuals. Recent advances have highlighted the essential role of immune processes in the …
[HTML][HTML] DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88
Alu RNA accumulation due to DICER1 deficiency in the retinal pigmented epithelium (RPE)
is implicated in geographic atrophy (GA), an advanced form of age-related macular …
is implicated in geographic atrophy (GA), an advanced form of age-related macular …
Nucleoside reverse transcriptase inhibitors possess intrinsic anti-inflammatory activity
Nucleoside reverse transcriptase inhibitors (NRTIs) are mainstay therapeutics for HIV that
block retrovirus replication. Alu (an endogenous retroelement that also requires reverse …
block retrovirus replication. Alu (an endogenous retroelement that also requires reverse …
cGAS drives noncanonical-inflammasome activation in age-related macular degeneration
Geographic atrophy is a blinding form of age-related macular degeneration characterized
by retinal pigmented epithelium (RPE) death; the RPE also exhibits DICER1 deficiency, …
by retinal pigmented epithelium (RPE) death; the RPE also exhibits DICER1 deficiency, …
[HTML][HTML] TLR-independent and P2X7-dependent signaling mediate Alu RNA-induced NLRP3 inflammasome activation in geographic atrophy
Purpose.: Accumulation of Alu RNA transcripts due to DICER1 deficiency in the retinal
pigmented epithelium (RPE) promotes geographic atrophy. Recently we showed that Alu RNA …
pigmented epithelium (RPE) promotes geographic atrophy. Recently we showed that Alu RNA …
Endothelial cell PECAM-1 promotes atherosclerotic lesions in areas of disturbed flow in ApoE-deficient mice
…, AC Bruce, AW Pryor, BD Gelfand… - … , and vascular biology, 2008 - Am Heart Assoc
Objective— Platelet endothelial cell adhesion molecule-1 (PECAM-1, CD31) has recently
been shown to form an essential element of a mechanosensory complex that mediates …
been shown to form an essential element of a mechanosensory complex that mediates …
Atheroprone hemodynamics regulate fibronectin deposition to create positive feedback that sustains endothelial inflammation
Rationale: The extracellular matrix protein fibronectin (FN) is focally deposited in regions of
atherosclerosis, where it contributes to inflammatory signaling. Objective: To elucidate the …
atherosclerosis, where it contributes to inflammatory signaling. Objective: To elucidate the …
ERK1/2 activation is a therapeutic target in age-related macular degeneration
…, ME Kleinman, JZ Baffi, BD Gelfand… - Proceedings of the …, 2012 - National Acad Sciences
Deficient expression of the RNase III DICER1, which leads to the accumulation of cytotoxic
Alu RNA, has been implicated in degeneration of the retinal pigmented epithelium (RPE) in …
Alu RNA, has been implicated in degeneration of the retinal pigmented epithelium (RPE) in …
[HTML][HTML] Human haemodynamic frequency harmonics regulate the inflammatory phenotype of vascular endothelial cells
RE Feaver, BD Gelfand, BR Blackman - Nature communications, 2013 - nature.com
Haemodynamic variations are inherent to blood vessel geometries (such as bifurcations)
and correlate with regional development of inflammation and atherosclerosis. However, the …
and correlate with regional development of inflammation and atherosclerosis. However, the …