Sleep disorders are a group of conditions that affect the ability to sleep well on a regular basis
and cause significant impairments in social and occupational functions. Although currently …

Glutamate dehydrogenase (GDH) is a homohexameric enzyme that catalyzes the reversible
oxidative deamination of l-glutamate to 2-oxoglutarate. Only in the animal kingdom is this …

All forms of diabetes share the common etiology of insufficient pancreatic β-cell function to
meet peripheral insulin demand. In pancreatic β-cells, mitochondria serve to integrate the …

Mesenchymal stem cells (MSCs) reportedly inhibit the mixed lymphocyte reaction. Whether
this effect is mediated by dendritic cells (DCs) is still unknown. In this study, we used an in …

Pdx1 is a homeobox-containing transcription factor that plays a key role in pancreatic
development and adult β cell function. In this study, we traced the fate of adult β cells after Pdx1 …

The proto-oncogene c-Myc paradoxically activates both proliferation and apoptosis. In the
pathogenic state, c-Myc–induced apoptosis is bypassed via a critical, yet poorly understood …

During insulin-resistant states such as type II diabetes mellitus (T2DM), insulin fails to suppress
hepatic glucose production (HGP) yet promotes lipid synthesis. This metabolic state has …

Despite unsurpassed anti-tumor activity of bortezomib for multiple myeloma (MM), drug
resistance has emerged as a challenge, especially when MM cells adhere to the stroma. This …

Aging is driven by changes of the epigenetic state that are only partially understood. We
performed a comprehensive epigenomic analysis of the pancreatic β cell, key player in glucose …

Insulin secretion by pancreatic β-cells is stimulated by glucose, amino acids, and other
metabolic fuels. Glutamate dehydrogenase (GDH) has been shown to play a regulatory role in …