This paper presents the conclusions of a workshop entitled ‘Impact of Molecular Genetics
on the Classification of Renal Cell Tumours’, which was held in Heidelberg in October 1996. …

Cancers emerge from an ongoing Darwinian evolutionary process, often leading to multiple
competing subclones within a single primary tumour 1 , 2 , 3 , 4 . This evolutionary process …

Molecular cloning of the transforming gene from a chemically transformed human
osteosarcoma-derived cell line enables the gene to be mapped to chromosome 7 (7p11.4–7qter) …

Purpose Studies indicate that castration-resistant prostate cancer (CRPC) remains driven by
ligand-dependent androgen receptor (AR) signaling. To evaluate this, a trial of abiraterone …

Prostate cancer is the most common cancer affecting males in developed countries. It shows
consistent evidence of familial aggregation, but the causes of this aggregation are mostly …

The protein-kinase family is the most frequently mutated gene family found in human cancer
and faulty kinase enzymes are being investigated as promising targets for the design of …

Human synovial sarcomas contain a recurrent and specific chromosomal translocation t(X;18)(p11.2;q11.2).
By screening a synovial sarcoma cDNA library with a yeast artificial …

The met oncogene activated in vitro by treatment of a human osteogenic sarcoma (HOS) cell
line with N-methyl-N’-nitronitrosoguanidine(MNNG) is related to the tyrosine kinase gene …

Prostate cancer is the most frequently diagnosed cancer in males in developed countries.
To identify common prostate cancer susceptibility alleles, we genotyped 211,155 SNPs on a …

Hormone-driven expression of the ERG oncogene after fusion with TMPRSS2 occurs in 30%
to 70% of therapy-naive prostate cancers. Its relevance in castration-resistant prostate …