Pigs and humans with cystic fibrosis have reduced insulin-like growth factor 1 (IGF1) levels at birth

…, RS Prather, J Zabner, DC Fredericks… - Proceedings of the …, 2010 - National Acad Sciences
People with cystic fibrosis (CF) exhibit growth defects. That observation has been attributed,
in part, to decreased insulin-like growth factor 1 (IGF1) levels, and the reduction has been …

Effects of pulsed electromagnetic fields on bone healing in a rabbit tibial osteotomy model

DC Fredericks, JV Nepola, JT Baker… - … of orthopaedic trauma, 2000 - journals.lww.com
Objective: The purpose of this study was to determine the effect of pulsed electromagnetic
field (PEMF) exposure on healing tibial osteotomies in New Zealand White rabbits. Design: …

Targeting mitochondrial responses to intra-articular fracture to prevent posttraumatic osteoarthritis

…, AS Morris, AK Salem, DC Fredericks… - Science translational …, 2018 - science.org
We tested whether inhibiting mechanically responsive articular chondrocyte mitochondria
after severe traumatic injury and preventing oxidative damage represent a viable paradigm for …

Regeneration of bone using nanoplex delivery of FGF-2 and BMP-2 genes in diaphyseal long bone radial defects in a diabetic rabbit model

…, E Petersen, B Guetschow, DC Fredericks… - Journal of controlled …, 2017 - Elsevier
Bone fracture healing impairment related to systemic diseases such as diabetes can be
addressed by growth factor augmentation. We previously reported that growth factors such as …

Instability dependency of osteoarthritis development in a rabbit model of graded anterior cruciate ligament transection

Y Tochigi, T Vaseenon, AD Heiner, DC Fredericks… - JBJS, 2011 - journals.lww.com
Background: Joint instability has long been empirically recognized as a leading risk factor
for osteoarthritis. However, formal mechanistic linkage of instability to osteoarthritis …

Biomechanical analysis of cervical disc replacement and fusion using single level, two level, and hybrid constructs

…, NM Grosland, JD Smucker, DC Fredericks - Spine, 2015 - journals.lww.com
Study Design. A biomechanical study comparing arthroplasty with fusion using human
cadaveric C2–T1 spines. Objective. To compare the kinematics of the cervical spine after …

Vertical shear injuries: is there a relationship between residual displacement and functional outcome?

…, SL Butterfield, DC Fredericks… - Journal of Trauma …, 1999 - journals.lww.com
Background Residual vertical displacement is often cited as being related to poor outcome
in patients with pelvic injuries. This study attempts to clarify the relationship between residual …

Characteristics of meniscus progenitor cells migrated from injured meniscus

…, AD Lehman, KW Jang, DC Fredericks… - Journal of …, 2017 - Wiley Online Library
Serious meniscus injuries seldom heal and increase the risk for knee osteoarthritis; thus,
there is a need to develop new reparative therapies. In that regard, stimulating tissue …

Effects of pulsed electromagnetic field stimulation on distraction osteogenesis in the rabbit tibial leg lengthening model

DC Fredericks, DJ Piehl, JT Baker… - Journal of pediatric …, 2003 - journals.lww.com
The purpose of this study was to determine whether exposure to pulsed electromagnetic
field (PEMF) would shorten the healing time of regenerate bone in a rabbit tibial distraction …

Time‐dependent loss of mitochondrial function precedes progressive histologic cartilage degeneration in a rabbit meniscal destabilization model

JE Goetz, MC Coleman, DC Fredericks… - Journal of …, 2017 - Wiley Online Library
The goals of this work were to characterize progression of osteoarthritic cartilage degeneration
in a rabbit medial meniscus destabilization (MMD) model and then to use the model to …