The heat and capsaicin receptor, TRPV1, is required for the detection of painful heat by primary
afferent pain fibers (nociceptors), but the extent to which functional TRPV1 channels are …

Behavioral responses to painful stimuli require peripheral sensory neurons called
nociceptors. Electrophysiological studies show that most C-fiber nociceptors are polymodal (ie, …

Circadian rhythms allow animals to coordinate behavioral and physiological processes with
respect to one another and to synchronize these processes to external environmental cycles…

Primary afferent “pain” fibers (nociceptors) are divided into subclasses based on distinct
molecular and anatomical features, and these classes mediate noxious modality-specific …

Though much is known about the cellular and molecular components of the circadian clock,
output pathways that couple clock cells to overt behaviors have not been identified. We …

Although the formalin test is a widely used model of persistent pain, the primary afferent fiber
types that underlie the cellular and behavioral responses to formalin injection are largely …

The mechanisms by which clock neurons in the Drosophila brain confer an ∼24-hr rhythm
onto locomotor activity are unclear, but involve the neuropeptide diuretic hormone 44 (DH44), …

The result of experiments conducted in this laboratory to determine the fate of virulent strains
of Pasteurella pestis inoculated into an animal host by a blocked flea led to an examination …

Background: Prophylactic systemic antibiotics significantly lower the risk of postoperative
infection, and injection of antibiotics directly into the wound cavity has been found to be even …

Key points Ablation of TRPV1+/peptidergic or of MrgprD+/non‐peptidergic nociceptors produces
modality‐specific deficits in the behavioural responses to heat and mechanical stimuli, …