User profiles for Jon T. Sims

Jonathan T. Sims

Eli Lilly & Company
Verified email at lilly.com
Cited by 1048

Vertebroplasty in patients with severe vertebral compression fractures: a technical report

JP O'Brien, JT Sims, AJ Evans - American Journal of …, 2000 - Am Soc Neuroradiology
Vertebroplasty is a procedure in which polymethylmethacrylate (PMMA) is injected into a
vertebral body compression fracture. It has been suggested that fractures greater than 65% to …

[HTML][HTML] Characterization of the cytokine storm reflects hyperinflammatory endothelial dysfunction in COVID-19

JT Sims, V Krishnan, CY Chang, SM Engle… - Journal of Allergy and …, 2021 - Elsevier
… Author links open overlay panel Jonathan T. Sims PhD a ∗ , Venkatesh Krishnan PhD a
∗ , Ching-Yun Chang PhD a , Sarah M. Engle MS a , Giacomo Casalini MD b , George H. …

Imatinib reverses doxorubicin resistance by affecting activation of STAT3-dependent NF-κB and HSP27/p38/AKT pathways and by inhibiting ABCB1

JT Sims, SS Ganguly, H Bennett, JW Friend, J Tepe… - PloS one, 2013 - journals.plos.org
Despite advances in cancer detection and prevention, a diagnosis of metastatic disease
remains a death sentence due to the fact that many cancers are either resistant to …

c-Abl and Arg are activated in human primary melanomas, promote melanoma cell invasion via distinct pathways, and drive metastatic progression

SS Ganguly, LS Fiore, JT Sims, JW Friend… - Oncogene, 2012 - nature.com
Despite 35 years of clinical trials, there is little improvement in 1-year survival rates for
patients with metastatic melanoma, and the disease is essentially untreatable if not cured …

Anaplasma phagocytophilum APH_0032 is expressed late during infection and localizes to the pathogen-occupied vacuolar membrane

B Huang, MJ Troese, D Howe, S Ye, JT Sims… - Microbial …, 2010 - Elsevier
Anaplasma phagocytophilum infects neutrophils and myeloid, endothelial, and tick cell lines
to reside within a host cell-derived vacuole that is indispensible for its survival. Here, we …

MTT assays cannot be utilized to study the effects of STI571/Gleevec on the viability of solid tumor cell lines

JT Sims, R Plattner - Cancer chemotherapy and pharmacology, 2009 - Springer
Purpose This study will determine whether MTT assays accurately assess the effect of STI571
(Gleevec; Abl kinase inhibitor) on the viability of cancer cells containing highly active Abl …

Anaplasma phagocytophilum APH_1387 Is Expressed throughout Bacterial Intracellular Development and Localizes to the Pathogen-Occupied Vacuolar Membrane

B Huang, MJ Troese, S Ye, JT Sims… - Infection and …, 2010 - Am Soc Microbiol
Obligate vacuolar pathogens produce proteins that localize to the host cell-derived membranes
of the vacuoles in which they reside, yielding unique organelles that are optimally suited …

Cytokines and Epidermal Lipid Abnormalities in Atopic Dermatitis: A Systematic Review

…, L Seminario-Vidal, B Abe, C Ghobadi, JT Sims - Cells, 2023 - mdpi.com
Atopic dermatitis (AD) is the most common chronic inflammatory skin disease and presents
a major public health problem worldwide. It is characterized by a recurrent and/or chronic …

[PDF][PDF] Jonathan T. Sims, Josh Poorbaugh, Ching‑Yun Chang, Timothy R. Holzer, Lin Zhang, Sarah M. Engle, Stephanie Beasley, Thompson N. Doman, Lynn …

RJ Benschop - 2022 - … -medicine.biomedcentral.com
Background: A thorough understanding of a patient’s inflammatory response to Severe Acute
Respiratory Syndrome Coronavirus 2 (SARS‑CoV‑2) infection is crucial to discerning the …

Abstract C51: c-Abl and Arg are activated in human primary melanomas, promote melanoma cell invasion, proliferation, survival, and drive metastatic progression

SS Ganguly, LS Fiore, JT Sims, JW Friend… - Cancer Research, 2013 - AACR
Despite 40 years of clinical trials, there has been little improvement in one-year survival
rates for patients with metastatic melanoma, and the disease is essentially untreatable if not …