User profiles for KELLY GRIMES

Kelly Grimes

Cincinnati Children's Hospital
Verified email at cchmc.org
Cited by 605

[HTML][HTML] Thbs1 induces lethal cardiac atrophy through PERK-ATF4 regulated autophagy

D Vanhoutte, TG Schips, A Vo, KM Grimes… - Nature …, 2021 - nature.com
The thrombospondin (Thbs) family of secreted matricellular proteins are stress- and injury-induced
mediators of cellular attachment dynamics and extracellular matrix protein production. …

Blue-blocking IOLs: a complete review of the literature

BA Henderson, KJ Grimes - Survey of ophthalmology, 2010 - Elsevier
Intraocular lenses (IOLs) that block both ultraviolet and blue wavelength light (<500 nm)
were introduced in the 1990s. Since then, the potential benefits and harm from blocking blue …

A human FLII gene variant alters sarcomeric actin thin filament length and predisposes to cardiomyopathy

…, SC Lin, MA Sargent, KM Grimes… - Proceedings of the …, 2023 - National Acad Sciences
To better understand the genetic basis of heart disease, we identified a variant in the Flightless-I
homolog (FLII) gene that generates a R1243H missense change and predisposes to …

[HTML][HTML] ERK1/2 signaling induces skeletal muscle slow fiber-type switching and reduces muscular dystrophy disease severity

JG Boyer, V Prasad, T Song, D Lee, X Fu, KM Grimes… - JCI insight, 2019 - ncbi.nlm.nih.gov
MAPK signaling consists of an array of successively acting kinases. ERK1 and-2 (ERK1/2)
are major components of the greater MAPK cascade that transduce growth factor signaling at …

MCUb induction protects the heart from postischemic remodeling

J Huo, S Lu, JQ Kwong, MJ Bround, KM Grimes… - Circulation …, 2020 - Am Heart Assoc
Rationale: Mitochondrial Ca 2+ loading augments oxidative metabolism to match functional
demands during times of increased work or injury. However, mitochondrial Ca 2+ overload …

[HTML][HTML] Age-related changes in the proteostasis network in the brain of the naked mole-rat: implications promoting healthy longevity

…, A Tramutola, A Swomley, J Kirk, K Grimes… - … et Biophysica Acta (BBA …, 2015 - Elsevier
The naked mole-rat (NMR) is the longest-lived rodent and possesses several exceptional
traits: marked cancer resistance, negligible senescence, prolonged genomic integrity, …

Establishing consensus on the best practice guidelines for the use of bracing in adolescent idiopathic scoliosis

…, P Bakarania, H Berdishevsky, LA Dolan, K Grimes… - Spine deformity, 2020 - Springer
Study design Survey. Objectives Bracing is the mainstay of conservative treatment in
Adolescent Idiopathic Scoliosis (AIS). The purpose of this study was to establish best practice …

Stepwise approach to establishing an ophthalmology wet laboratory

BA Henderson, KJ Grimes, RE Fintelmann… - Journal of Cataract & …, 2009 - Elsevier
Wet laboratories (wet labs) play an increasingly important role in ophthalmology surgical
residency training. We summarize the necessary components in establishing and maintaining a …

And the beat goes on: maintained cardiovascular function during aging in the longest-lived rodent, the naked mole-rat

KM Grimes, AK Reddy, ML Lindsey… - American Journal of …, 2014 - journals.physiology.org
… *KM Grimes and AK Reddy contributed equally to this work. … *KM Grimes and AK Reddy
contributed equally to this work. … * KM Grimes and AK Reddy contributed equally to this work. …

Return on investment in healthcare leadership development programs

…, F Farshidfar, J Lys, G Dickson, K Grimes… - Leadership in Health …, 2018 - emerald.com
Purpose Strong leadership has been shown to foster change, including loyalty, improved
performance and decreased error rates, but there is a dearth of evidence on effectiveness of …