Background Lumbar disc arthroplasty (total disc replacement [TDR]) outcomes have been
evaluated using subjective, patient-reported measures of pain, health, and functional …

Localizationists generally accept that the left cerebral hemisphere in most individuals is
responsible for speech and language and the right cerebral hemisphere is responsible for …

Purpose Tumour budding (TB) is an adverse histological feature in many epithelial cancers.
It is thought to represent epithelial–mesenchymal transition, a key step in the metastatic …

We report a genome-wide association study of melanoma conducted by the GenoMEL
consortium based on 317K tagging SNPs for 1,650 selected cases and 4,336 controls, with …

Previous genome-wide association studies (GWAS) have identified six risk loci for renal cell
carcinoma (RCC). We conducted a meta-analysis of two new scans of 5,198 cases and …

The Event Horizon Telescope (EHT) is a very long baseline interferometry (VLBI) array that
comprises millimeter-and submillimeter-wavelength telescopes separated by distances …

Background Several obesity-related factors have been associated with renal cell carcinoma
(RCC), but it is unclear which individual factors directly influence risk. We addressed this …

Despite initial responses 1 , 2 – 3 , most melanoma patients develop resistance 4 to immune
checkpoint blockade (ICB). To understand the evolution of resistance, we studied 37 tumor …

… A simple extrapolation from past increases in animal production indicates that we should
be able to meet this demand if past rates of increase can be sustained (Boland et al., 2013). …

Patients with acute aortic dissection (AAD) have an in-hospital mortality of 26%, and for those
patients with type A AAD, the mortality risk is 1% to 2% per hour until emergency surgical …