Cyclooxygenase (COX), the key enzyme required for the conversion of arachidonic acid to
prostaglandins was first identified over 20 years ago. Drugs, like aspirin, that inhibit …

Many patients with chronic pain do not obtain adequate relief or experience unacceptable
side effects from existing treatments. Moreover, even when clinical trials report positive …

A meta-analysis was performed to evaluate the accuracy of determination of procalcitonin (PCT)
and C-reactive protein (CRP) levels for the diagnosis of bacterial infection. The analysis …

Monte Carlo simulation is an essential tool in emission tomography that can assist in the
design of new medical imaging devices, the optimization of acquisition protocols and the …

ContextConventional nonsteroidal anti-inflammatory drugs (NSAIDs) are associated with a
spectrum of toxic effects, notably gastrointestinal (GI) effects, because of inhibition of …

Objective Remission in rheumatoid arthritis (RA) is an increasingly attainable goal, but there
is no widely used definition of remission that is stringent but achievable and could be …

… LEON SIMON … Simon, LM (Leon Melvin), 1945Lectures on geometric measure theory. …

Objective. To provide recommendations for the core outcome domains that should be considered
by investigators conducting clinical trials of the efficacy and effectiveness of treatments …

Background Low-risk limits recommended for alcohol consumption vary substantially across
different national guidelines. To define thresholds associated with lowest risk for all-cause …

Background: The OARSI Standing Committee for Clinical Trials Response Criteria Initiative
had developed two sets of responder criteria to present the results of changes after treatment …