Preclinical evaluation of pulsed field ablation: electrophysiological and histological assessment of thoracic vein isolation

…, R Brose, ED Buck, M Speltz… - Circulation …, 2019 - Am Heart Assoc
Background: Pulsed field ablation (PFA) is a uniquely tissue-selective, nonthermal cardiac
ablation modality. Delivery parameters such as the electrical waveform composition and …

Pulsed field ablation of left ventricular myocardium in a swine infarct model

…, E Buck, B Morrow, K Schenider, M Speltz… - Clinical …, 2022 - jacc.org
Background Pulsed field ablation (PFA) leads to cell death by irreversible electroporation.
There are limited data about PFA lesion characteristics in the ventricle, particularly in the …

Electrophysiology, pathology, and imaging of pulsed field ablation of scarred and healthy ventricles in swine

…, S Jerrell, CW Schneider, M Speltz… - Circulation …, 2023 - Am Heart Assoc
Background: Pulsed field ablation (PFA) has recently been shown to penetrate ischemic scar,
but details on its efficacy, risk of arrhythmias, and imaging insights are lacking. In a porcine …

Effect of epicardial pulsed field ablation directly on coronary arteries

…, ED Buck, S Jerrell, CW Schneider, M Speltz… - Clinical …, 2022 - jacc.org
Background The unique tissue selectivity of pulsed field ablation (PFA) allows for minimizing
collateral damage to the nerves/esophagus. However, the safety profile of epicardial PFA …

Equine intervertebral disk disease: a case report

MC Speltz, EJ Olson, LM Hunt, RR Pool… - Journal of equine …, 2006 - Elsevier
Intervertebral disk disease is common in humans and dogs but is rarely reported in horses.
In this case report, we describe an 11-year-old American Saddlebred gelding with a 2-month …

Evaluation of a novel cryoprobe for atrial ablation in a chronic ovine model

MR Schill, SJ Melby, M Speltz, M Breitbach… - The Annals of thoracic …, 2017 - Elsevier
Purpose Cryoablation is used in the treatment of atrial fibrillation and other cardiac arrhythmias.
This study evaluated a novel 10-cm flexible nitrous oxide cryoprobe in an ovine model of …

Pathology in practice

MC Speltz, RR Pool, DW Hayden - Journal of the American …, 2009 - Am Vet Med Assoc
Histologic examination of sections of the excised tissues revealed a partially encapsulated,
moderately cellular, well-demarcated, infiltrative mass of neoplastic cells that effaced much of …

Preclinical comparison of thermal tissue effects from traditional electrosurgery and a low-temperature electrosurgical device during anterior cervical discectomy and …

K Radcliff, P Vijay, RF Sarris, M Speltz… - International Journal of …, 2018 - ijssurgery.com
Background: Exposure of the anterior cervical spine requires dissection in proximity to
critical neurovascular structures. Monopolar electrosurgical (ES) devices generate heat in …

Comparison of a Saline-coupled Bipolar Sealer Versus Traditional Electrosurgery in a Porcine Model of Chronic Wound Healing.

DJ Griffin, P Vijay, M Speltz, N Kirchhof… - … : a Compendium of …, 2017 - europepmc.org
OBJECTIVE: This study examines the healing dynamics of in vivo porcine muscle tissue
wounds hemostatically treated with a saline-coupled bipolar tissue sealer (SCBS) compared …

Averaged Impedance Drop Workflow for Pulmonary Vein Isolation

…, JH Tranter, J Overmann, I Husain, M Speltz… - Circulation, 2023 - Am Heart Assoc
Background: Previous studies demonstrate that averaged impedance drop (AID) is the most
accurate predictor of focal atrial RF ablation lesion transmurality when using the TactiFlex™ …