Studies of alternative isoforms provide insight into TDP-43 autoregulation and pathogenesis
S D'Alton, M Altshuler, J Lewis - Rna, 2015 - rnajournal.cshlp.org
TDP-43 is a soluble, nuclear protein that undergoes cytoplasmic redistribution and
aggregation in the majority of cases of amyotrophic lateral sclerosis and frontotemporal lobar …
aggregation in the majority of cases of amyotrophic lateral sclerosis and frontotemporal lobar …
Does minimally invasive spine surgery improve outcomes in the obese population? A retrospective review of 1442 degenerative lumbar spine surgeries
…, E Dowlati, E Molina, D Zhao, M Altshuler… - … of Neurosurgery: Spine, 2021 - thejns.org
OBJECTIVE The effect of obesity on outcomes in minimally invasive surgery (MIS) approaches
to posterior lumbar surgery is not well characterized. The authors aimed to determine if …
to posterior lumbar surgery is not well characterized. The authors aimed to determine if …
Does minimally invasive spine surgery reduce the rate of perioperative medical complications? A retrospective single-center experience of 1435 degenerative lumbar …
M Altshuler, K Mueller, A MacConnell, P Wirth… - European Spine …, 2021 - Springer
Purpose It is unclear if minimally invasive techniques reduce the rate of perioperative
complications when compared to traditional open approaches to the lumbar spine. Our aim was to …
complications when compared to traditional open approaches to the lumbar spine. Our aim was to …
[HTML][HTML] Divergent phenotypes in mutant TDP-43 transgenic mice highlight potential confounds in TDP-43 transgenic modeling
S D'Alton, M Altshuler, A Cannon, DW Dickson… - PloS one, 2014 - journals.plos.org
The majority of cases of frontotemporal lobar degeneration and amyotrophic lateral sclerosis
are pathologically defined by the cleavage, cytoplasmic redistribution and aggregation of …
are pathologically defined by the cleavage, cytoplasmic redistribution and aggregation of …
The diagnosis and natural history of Huntington disease
F Pagan, Y Torres-Yaghi, M Altshuler - Handbook of clinical neurology, 2017 - Elsevier
Huntington disease (HD) is an autosomal-dominant disorder resulting from CAG triplet
repeats, which leads to an expanded polyglutamine sequence in the HTT (Huntingtin) protein. …
repeats, which leads to an expanded polyglutamine sequence in the HTT (Huntingtin) protein. …
Partial loss of ATP13A2 causes selective gliosis independent of robust lipofuscinosis
…, YB Seven, J Howard, C Duffy, M Altshuler… - Molecular and Cellular …, 2018 - Elsevier
Loss-of-function mutations in ATP13A2 are associated with three neurodegenerative diseases:
a rare form of Parkinson's disease termed Kufor-Rakeb syndrome (KRS), a lysosomal …
a rare form of Parkinson's disease termed Kufor-Rakeb syndrome (KRS), a lysosomal …
Chronic neuronal activation leads to elevated lactate dehydrogenase A through the AMP-activated protein kinase/hypoxia-inducible factor-1α hypoxia pathway
A Ksendzovsky, M Bachani, M Altshuler… - Brain …, 2023 - academic.oup.com
Recent studies suggest that changes in neuronal metabolism are associated with epilepsy.
High rates of ATP depletion, lactate dehydrogenase A and lactate production have all been …
High rates of ATP depletion, lactate dehydrogenase A and lactate production have all been …
Elevated risk of recurrence and retreatment for silent pituitary adenomas
Purpose Pituitary adenomas are the most common tumor of the pituitary gland and comprise
nearly 15% of all intracranial masses. These tumors are stratified into functional or silent …
nearly 15% of all intracranial masses. These tumors are stratified into functional or silent …
Comparison of clinical and radiographic outcomes after standalone versus cage and plate constructs for anterior cervical discectomy and fusion
…, G Keating, KD Cobourn, M Altshuler… - International Journal of …, 2021 - ijssurgery.com
Background: Anterior cervical discectomy and fusion (ACDF) has conventionally been
performed using an allograft cage with a plate-and-screw construct. Recently, standalone cages …
performed using an allograft cage with a plate-and-screw construct. Recently, standalone cages …
Strategies to improve surgical technical competency: a systematic review
L Banko, RV Patel, N Nawabi, M Altshuler… - Acta …, 2023 - Springer
Background A cornerstone of surgical residency training is an educational program that
produces highly skilled and effective surgeons. Training structures are constantly being revised …
produces highly skilled and effective surgeons. Training structures are constantly being revised …