Discovery and structure− activity relationship of quinuclidine benzamides as agonists of α7 nicotinic acetylcholine receptors
…, JK Myers, BN Rogers, TM Wall, ML Wolfe… - Journal of medicinal …, 2005 - ACS Publications
A library of benzamides was tested for α7 nicotinic acetylcholine receptor (nAChR) agonist
activity using a chimeric receptor in a functional, cell-based, high-throughput assay. From this …
activity using a chimeric receptor in a functional, cell-based, high-throughput assay. From this …
Discovery of N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an Agonist of the α7 Nicotinic Acetylcholine Receptor, for the Potential Treatment …
…, KL Olson, EJ Jacobsen, ML Wolfe… - Journal of medicinal …, 2006 - ACS Publications
N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide (14, PHA-543,613), a
novel agonist of the α7 neuronal nicotinic acetylcholine receptor (α7 nAChR), has been …
novel agonist of the α7 neuronal nicotinic acetylcholine receptor (α7 nAChR), has been …
Characterization of the steady-state and dynamic fluorescence properties of the potential-sensitive dye bis-(1, 3-dibutylbarbituric acid) trimethine oxonol (Dibac4 (3)) in …
DE Epps, ML Wolfe, V Groppi - Chemistry and physics of lipids, 1994 - Elsevier
The steady-state and dynamic fluorescence properties of the membrane potential-sensitive
bis-oxonol dye Dibac 4 (3) were characterized in vitro using model ligand systems and in …
bis-oxonol dye Dibac 4 (3) were characterized in vitro using model ligand systems and in …
Design, synthesis, structure–activity relationship, and in vivo activity of azabicyclic aryl amides as α7 nicotinic acetylcholine receptor agonists
…, EJ Jacobsen, BA Acker, VE Groppi, ML Wolfe… - Bioorganic & medicinal …, 2006 - Elsevier
A novel set of azabicyclic aryl amides have been identified as potent and selective agonists
of the α7 nAChR. A two-pronged approach was taken to improve the potential hERG liability …
of the α7 nAChR. A two-pronged approach was taken to improve the potential hERG liability …
Discovery of N-[(3R, 5R)-1-azabicyclo [3.2. 1] oct-3-yl] furo [2, 3-c] pyridine-5-carboxamide as an agonist of the α7 nicotinic acetylcholine receptor: In vitro and in vivo …
…, SC Reitz, DW Piotrowski, JK Myers, ML Wolfe… - Bioorganic & Medicinal …, 2008 - Elsevier
A novel α7 nAChR agonist, N-[(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide
(3a, PHA-709829), has been identified for the potential treatment of cognitive …
(3a, PHA-709829), has been identified for the potential treatment of cognitive …
Synthesis and biological activity of spirocyclic benzopyran imidazolone potassium channel openers
…, BV Kamdar, LAC Dubray, ML Wolfe… - Journal of medicinal …, 1993 - ACS Publications
A series of novel spirocyclic benzopyran imidazolones were synthesized as rigid analogues
of cromakalim. These compounds cause a dose-dependent membrane hyperpolarization of …
of cromakalim. These compounds cause a dose-dependent membrane hyperpolarization of …
Fortifying the bone-implant interface part 1: an in vitro evaluation of 3D-printed and TPS porous surfaces
…, CS Bahney, SA Woods, ML Wolfe… - International journal of …, 2017 - ijssurgery.com
Background An aging society and concomitant rise in the incidence of impaired bone health
have led to the need for advanced osteoconductive spinal implant surfaces that promote …
have led to the need for advanced osteoconductive spinal implant surfaces that promote …
The Vocational Education Act of 1963, as Amended: A Background Paper.
ML Wolfe - 1978 - ERIC
The federal role in vocational education from the Smith Hughes Act of 1917 (Public Law 68-35)
through the Vocational Education Act of 1963 (Public Law 88-210), as amended in 1976, …
through the Vocational Education Act of 1963 (Public Law 88-210), as amended in 1976, …
Student Loan Guarantee Agencies and Their Financing. A Working Paper.
JS Hansen, ML Wolfe - 1985 - ERIC
Guarantee agencies and their financing are discussed in order to increase awareness of their
role and to provide information for policy decisions. Information is provided on: the history …
role and to provide information for policy decisions. Information is provided on: the history …
The Career Education Incentive Act: A Background Paper. Report No. 79-23-EPW.
ML Wolfe - 1979 - ERIC
This report discusses the current federal role in career education under the Career Education
Incentive Act (PL 95-207), which authorizes a federal formula grant program to states and …
Incentive Act (PL 95-207), which authorizes a federal formula grant program to states and …