The choroid plexus epithelium (CPE) secretes higher volumes of fluid (cerebrospinal fluid,
CSF) than any other epithelium and simultaneously functions as the blood–CSF barrier to …

Congenital hydrocephalus (CH), characterized by enlarged brain ventricles, is considered a
disease of excessive cerebrospinal fluid (CSF) accumulation and thereby treated with …

BACKGROUND: Although current guidelines for the management of unruptured intracranial
aneurysms (IAs) suggest aneurysms larger than 7 mm should be considered for treatment, a …

10.7554/eLife.20125.001 Premature fusion of the cranial sutures (craniosynostosis),
affecting 1 in 2000 newborns, is treated surgically in infancy to prevent adverse neurologic …

The choroid plexus (ChP) is the blood-cerebrospinal fluid (CSF) barrier and the primary
source of CSF. Acquired hydrocephalus, caused by brain infection or hemorrhage, lacks drug …

Congenital hydrocephalus (CH), featuring markedly enlarged brain ventricles, is thought to
arise from failed cerebrospinal fluid (CSF) homeostasis and is treated with lifelong surgical …

Hydrocephalus, despite its heterogeneous causes, is ultimately a disease of disordered CSF
homeostasis that results in pathological expansion of the cerebral ventricles. Our current …

Mutations in Krev1 interaction trapped gene 1 (KRIT1) cause cerebral cavernous malformation,
an autosomal dominant disease featuring malformation of cerebral capillaries resulting …

Normal vascular development includes the formation and specification of arteries, veins, and
intervening capillaries. Vein of Galen malformations (VOGMs) are among the most common …

The identification of pathways that underlie common disease has been greatly impacted by
the study of rare families that segregate single genes with large effect. Intracranial aneurysm …