One of the impediments to the treatment of brain tumors (eg, gliomas) has been the degree
to which they expand, infiltrate surrounding tissue, and migrate widely into normal brain, …

Purpose: This was an open-label, dose-escalation trial of intratumoral administration of IL-4Pseudomonas
exotoxin (NBI-3001) in patients with recurrent malignant glioma. Patients and …

The remarkable migratory and tumor-tropic capacities of neural stem cells (NSCs and/or
neuroprogenitor cells) represent a potentially powerful approach to the treatment of invasive …

Cationic liposomes (CL) are widely used vectors for gene transfer. Recently, ultrasound (US)
was reported to enhance liposome-mediated gene transfer to eucaryotic cells in culture. …

Background Glioma recurrence usually occurs close to the tumor resection margins as a
result of residual infiltrating glioma cells. 5-aminolevulinic acid (ALA) fluorescence-guided …

Cellular delivery of a replication-conditional herpes simplex virus type 1 (HSV-1) vector
provides a means for gene therapy of invasive tumor cells. LacZ-bearing neural precursor cells, …

Suicide gene transfer using thymidine kinase (TK) and ganciclovir (GCV) treatment or the
cytosine deaminase (CD)/5-fluorocytosine (5-FC) system represents the most widely used …

Continuous intrathecal infusion of analgesic drugs by implantable pumps is recognized as
an established treatment option for patients with chronic pain resistant to oral or parenteral …

MicroRNAs are single-stranded small non-coding RNA molecules which regulate mammalian
cell growth, differentiation, and apoptosis by altering the expression of other genes and …

Background: Risk factors and predisposing factors for the development of symptomatic
meningioma during adult life are not well known. Methods: Data from 306 consecutive patients …