eD octor: machine learning and the future of medicine

GS Handelman, HK Kok, RV Chandra… - Journal of internal …, 2018 - Wiley Online Library
Abstract Machine learning ( ML ) is a burgeoning field of medicine with huge resources
being applied to fuse computer science and statistics to medical problems. Proponents of ML …

[PDF][PDF] Peering into the black box of artificial intelligence: evaluation metrics of machine learning methods

GS Handelman, HK Kok, RV Chandra… - American Journal of …, 2019 - Am Roentgen Ray Soc
OBJECTIVE. Machine learning (ML) and artificial intelligence (AI) are rapidly becoming the
most talked about and controversial topics in radiology and medicine. Over the past few years…

A review of the management of cerebral vasospasm after aneurysmal subarachnoid hemorrhage

K Li, CD Barras, RV Chandra, HK Kok, JT Maingard… - World neurosurgery, 2019 - Elsevier
Background Despite decades of research, cerebral vasospasm (CV) continues to account
for high morbidity and mortality in patients who survive their initial aneurysmal subarachnoid …

[HTML][HTML] Endovascular therapy for ischemic stroke with perfusion-imaging selection

…, TG Phan, W Chong, RV Chandra… - … England Journal of …, 2015 - Mass Medical Soc
Background Trials of endovascular therapy for ischemic stroke have produced variable
results. We conducted this study to test whether more advanced imaging selection, recently …

[HTML][HTML] Tenecteplase versus alteplase before thrombectomy for ischemic stroke

…, H Ma, TG Phan, W Chong, RV Chandra… - … England Journal of …, 2018 - Mass Medical Soc
Background Intravenous infusion of alteplase is used for thrombolysis before endovascular
thrombectomy for ischemic stroke. Tenecteplase, which is more fibrin-specific and has longer …

Endovascular thrombectomy versus standard bridging thrombolytic with endovascular thrombectomy within 4· 5 H of stroke onset: an open-label, blinded-endpoint …

…, MD Ton, DJ Cordato, TJ Kleinig, H Ma, RV Chandra… - The Lancet, 2022 - thelancet.com
Background The benefit of combined treatment with intravenous thrombolysis before
endovascular thrombectomy in patients with acute ischaemic stroke caused by large vessel …

Effect of intravenous tenecteplase dose on cerebral reperfusion before thrombectomy in patients with large vessel occlusion ischemic stroke: the EXTEND-IA TNK part …

…, T Phan, S Singhal, J Ly, W Chong, RV Chandra… - Jama, 2020 - jamanetwork.com
Importance Intravenous thrombolysis with tenecteplase improves reperfusion prior to
endovascular thrombectomy for ischemic stroke compared with alteplase. Objective To determine …

A multicenter, randomized, controlled study to investigate EXtending the time for Thrombolysis in Emergency Neurological Deficits with Intra-Arterial therapy (EXTEND …

…, W Chong, ME Holt, RV Chandra… - … Journal of Stroke, 2014 - journals.sagepub.com
Background and Hypothesis Thrombolysis with tissue plasminogen activator is proven to
reduce disability when given within 4.5 h of ischemic stroke onset. However, tissue …

Interobserver reliability of baseline noncontrast CT Alberta Stroke Program Early CT Score for intra-arterial stroke treatment selection

…, TM Leslie-Mazwi, RV Chandra… - American Journal …, 2012 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: Early ischemic changes on pretreatment NCCT quantified
using ASPECTS have been demonstrated to predict outcomes after IAT. We sought to …

Vertebroplasty and kyphoplasty for osteoporotic vertebral fractures: what are the latest data?

RV Chandra, J Maingard, H Asadi… - American Journal …, 2018 - Am Soc Neuroradiology
Osteoporotic vertebral compression fractures frequently result in significant morbidity and
health care resource use. For patients with severe and disabling pain, vertebral augmentation (…