Cancers arise owing to mutations in a subset of genes that confer growth advantage. The
availability of the human genome sequence led us to propose that systematic resequencing of …

The usefulness of mobile devices has increased greatly in recent years allowing users to
perform more tasks in a mobile context. This increase in usefulness has come at the expense of …

This paper describes the results of an investigation into a set of metrics for object-oriented
design, called the MOOD metrics. The merits of each of the six MOOD metrics is discussed …

Pulmonary arterial hypertension (PAH) is clinically characterized by a sustained elevation in
mean pulmonary artery pressure leading to significant morbidity and mortality. The disorder …

Protein kinases are frequently mutated in human cancer and inhibitors of mutant protein
kinases have proven to be effective anticancer drugs. We screened the coding sequences of …

Malignant gliomas have a very poor prognosis. The current standard of care for these
cancers consists of extended adjuvant treatment with the alkylating agent temozolomide after …

The panel of 60 human cancer cell lines (the NCI-60) assembled by the National Cancer
Institute for anticancer drug discovery is a widely used resource. The NCI-60 has been …

Background: Mutations of the transforming growth factor β (TGFβ) receptor components
ENDOGLIN and ALK-1 cause the autosomal dominant vascular disorder hereditary …

Mobile app reviews are valuable repositories of ideas coming directly from app users. Such
ideas span various topics, and in this paper we show that 23.3% of them represent feature …

We examined the coding sequence of 518 protein kinases, ∼1.3 Mb of DNA per sample, in
25 breast cancers. In many tumors, we detected no somatic mutations. But a few had …