▪ Abstract Only 5 to 10% of immunocompetent humans are susceptible to tuberculosis, and
over 85% of them develop the disease exclusively in the lungs. Human immunodeficiency …

The term “activated macrophage” was introduced into the literature and employed extensively
by Mackaness in the 1960s to describe the enhanced microbicidal activity of macrophages …

Mutagenesis of the host immune system has helped identify response pathways necessary
to combat tuberculosis. Several such pathways may function as activators of a common …

Monocyte chemoattractant protein 1 (MCP-1) is a CC chemokine that attracts monocytes,
memory T lymphocytes, and natural killer cells. Because other chemokines have similar target …

On the basis of preceding studies showing that tumor-induced, T cell-mediated immunosuppression
serves as an obstacle to adoptive immunotherapy of the Meth A fibrosarcoma, it was …

Wild-type (WT) and targeted-mutant mice incapable of making αβ T cells, γδ T cells, class I
major histocompatibility complex (MHC), class II MHC, interferon (IFN)-γ, or inducible nitric …

Each equation in the model represents a “piece” of a dynamic system of simultaneous
equations, with the variables signaling the individual factors shaping the overall dynamics over …

We used gene targeting in embryonic stem cells to introduce an IL-lf3 null allele in mice. The
IL-lft-deficient mice develop normally and are apparently healthy and fertile. The IL-18 null …

The results of this paper are consistent with the hypothesis that progressive growth of the
Meth A fibrosarcoma evokes the generation of a T-cell-mediated mechanism of …

This study shows that in mice selectively depleted of neutrophils by treatment with a monoclonal
antibody, RB6-8C5, listeriosis is severely exacerbated in the liver, but not in the spleen …