Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
Eleven susceptibility loci for late-onset Alzheimer's disease (LOAD) were identified by previous
studies; however, a large portion of the genetic risk for this disease remains unexplained. …
studies; however, a large portion of the genetic risk for this disease remains unexplained. …
A graphene-based electrochemical device with thermoresponsive microneedles for diabetes monitoring and therapy
Owing to its high carrier mobility, conductivity, flexibility and optical transparency, graphene
is a versatile material in micro-and macroelectronics. However, the low density of …
is a versatile material in micro-and macroelectronics. However, the low density of …
Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
Risk for late-onset Alzheimer’s disease (LOAD), the most prevalent dementia, is partially
driven by genetics. To identify LOAD risk loci, we performed a large genome-wide association …
driven by genetics. To identify LOAD risk loci, we performed a large genome-wide association …
[HTML][HTML] Stretchable silicon nanoribbon electronics for skin prosthesis
Sensory receptors in human skin transmit a wealth of tactile and thermal signals from
external environments to the brain. Despite advances in our understanding of mechano- and …
external environments to the brain. Despite advances in our understanding of mechano- and …
[HTML][HTML] Analyses of pig genomes provide insight into porcine demography and evolution
For 10,000 years pigs and humans have shared a close and complex relationship. From
domestication to modern breeding practices, humans have shaped the genomes of domestic …
domestication to modern breeding practices, humans have shaped the genomes of domestic …
[HTML][HTML] Intravascular imaging–guided or angiography-guided complex PCI
Background Data regarding clinical outcomes after intravascular imaging–guided percutaneous
coronary intervention (PCI) for complex coronary-artery lesions, as compared with …
coronary intervention (PCI) for complex coronary-artery lesions, as compared with …
Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations
A key public health need is to identify individuals at high risk for a given disease to enable
enhanced screening or preventive therapies. Because most common diseases have a genetic …
enhanced screening or preventive therapies. Because most common diseases have a genetic …
Plane stress yield function for aluminum alloy sheets—part 1: theory
…, RE Dick, DJ Lege, F Pourboghrat, SH Choi… - International Journal of …, 2003 - Elsevier
A new plane stress yield function that well describes the anisotropic behavior of sheet metals,
in particular, aluminum alloy sheets, was proposed. The anisotropy of the function was …
in particular, aluminum alloy sheets, was proposed. The anisotropy of the function was …
[HTML][HTML] Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program
The Trans-Omics for Precision Medicine (TOPMed) programme seeks to elucidate the genetic
architecture and biology of heart, lung, blood and sleep disorders, with the ultimate goal of …
architecture and biology of heart, lung, blood and sleep disorders, with the ultimate goal of …
[HTML][HTML] A saturated map of common genetic variants associated with human height
…, LC Chang, YC Chang, CH Chen, A Chesi, SH Choi… - Nature, 2022 - nature.com
Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40–50%
of phenotypic variation in human height, but identifying the specific variants and …
of phenotypic variation in human height, but identifying the specific variants and …