The risk of accelerating the degeneration of adjacent disc levels after lumbar spinal fusion is
a controversial issue. A finite element model consisting of L1 to L5 lumbar spines was used …

We have reviewed recent progress in establishing the function of alpha-synuclein and
parkin in relation to nigral degeneration in autosomal dominant and autosomal recessive PD. …

Background The National Database of Health Insurance Claims and Specific Health Checkups
of Japan (NDB) is a comprehensive database of health insurance claims data under …

Although age- and season-specific effects on fracture risk have been reported, the effects of
seasonality across different age groups and for different fracture sites have not yet been …

Introduction This study was conducted to investigate the incidence and time trend of lower
limb amputation (LLA) among people with and without diabetes. Research design and …

PURPOSE: Psychotic symptoms in Parkinson's disease (PD) are relatively common and, in
addition to creating a disturbance in patients' daily lives, have consistently been shown to be …

Although paclitaxel plus bevacizumab (PB) therapy is an effective chemotherapeutic regimen
for HER2-negative advanced breast cancer (ABC), predictive markers for its effectiveness …

Prostaglandin (PG) E 2 induces dendritic cell maturation in cooperation with proinflammatory
cytokines [such as tumor necrosis factor (TNF)-α and interleukin (IL)-1β]. To clarify the …

Aims Although cardiac rehabilitation (CR) is a strongly recommended therapy, no large
study has assessed the effects of outpatient CR in patients with heart failure (HF) in real-world …

Introduction To investigate the incidence of type 1 diabetes by age group (0–19, 20–39, 40–59,
≥60 years) in Japan and whether there is seasonality in this incidence. Research …