Closed circulatory systems underlie the function of vertebrate organs, but in long bones their
structure is unclear although they constitute the exit route for bone marrow (BM) leukocytes. …

All of the over 1 million total joint replacements implanted in the US each year are expected
to eventually fail after 15–25 years of use, due to slow progressive subtle inflammation at the …

The treatments of avascular osteonecrosis (AVN) include both conservative and surgical
methods which are dependent on the stage and progression of the disease. The vasoactive-…

Purpose Treatment of full-thickness cartilage defects in the hip is a major issue for orthopaedic
surgeons. Autologous matrix-induced three-dimensional chondrocyte transplantation …

Background “Advanced Core Decompression” (ACD) is a new technique for treatment of
osteonecrosis of the femoral head (ONFH) that includes removal of the necrotic tissue using a …

Small-animal models are useful for the in vivo study of particle-induced osteolysis, the most
frequent cause of aseptic loosening after total joint replacement. Microstructural changes …

Cobalt alloy debris has been implicated as causative in the early failure of some designs of
current total joint implants. The ability of implant debris to cause excessive inflammation via …

Aseptic necrosis of the femoral head (AVN) leads to destruction of the affected hip joint,
predominantly in younger patients. Advanced core decompression (ACD) is a new technique …

Particle-induced osteolysis is a major cause of aseptic loosening after total joint replacement.
The purpose of the current study was to identify various apoptosis-related pathways in the …

There is still controversy as to whether minimally invasive total hip arthroplasty enhances the
postoperative outcome. The aim of this study was to compare the outcome of patients who …