Evaluation of polyphenols from Broussonetia papyrifera as coronavirus protease inhibitors

JY Park, HJ Yuk, HW Ryu, SH Lim, KS Kim… - Journal of enzyme …, 2017 - Taylor & Francis
The current study was designed to assess the inhibitory activity of Broussonetia papyrifera-derived
polyphenols against 3-chymotrypsin-like and papain-like coronavirus cysteine …

[HTML][HTML] The role of microglia in the development of neurodegenerative diseases

…, HJ Lee, SM Kim, JH Min, DY Kim, MO Kim, HW Ryu… - Biomedicines, 2021 - mdpi.com
Microglia play an important role in the maintenance and neuroprotection of the central
nervous system (CNS) by removing pathogens, damaged neurons, and plaques. Recent …

Geranylated flavonoids displaying SARS-CoV papain-like protease inhibition from the fruits of Paulownia tomentosa

…, MJ Curtis-Long, KH Lee, DW Kim, HW Ryu… - Bioorganic & medicinal …, 2013 - Elsevier
SARS-CoV papain-like protease (PLpro) is an important antiviral target due to its key roles in
SARS virus replication. The MeOH extracts of the fruits of the Paulownia tree yielded many …

α-Glucosidase inhibition and antihyperglycemic activity of prenylated xanthones from Garcinia mangostana

HW Ryu, JK Cho, MJ Curtis-Long, HJ Yuk, YS Kim… - Phytochemistry, 2011 - Elsevier
An ethanol extract of the fruit case of Garcinia mangostan, whose most abundant chemical
species are xanthones, showed potent α-glucosidase inhibitory activity (IC 50 =3.2μg/ml). A …

Sulfonamide chalcone as a new class of α-glucosidase inhibitors

WD Seo, JH Kim, JE Kang, HW Ryu… - Bioorganic & medicinal …, 2005 - Elsevier
Chalcones 1–20, a new class of glycosidase inhibitors, were synthesized, and their
glycosidase inhibitory activities were investigated. Non-aminochalcones 1–12 had no inhibitory …

Tyrosinase Inhibitory Polyphenols from Roots of Morus lhou

…, YB Ryu, MJ Curtis-Long, HW Ryu… - Journal of agricultural …, 2009 - ACS Publications
Twelve polyphenols (1−12) possessing tyrosinase inhibitory properties were isolated from
the methanol (95%) extract of Morus lhou. The isolated compounds consisted of four …

Polyphenols from Broussonetia papyrifera displaying potent α-glucosidase inhibition

HW Ryu, BW Lee, MJ Curtis-Long, S Jung… - Journal of agricultural …, 2010 - ACS Publications
The organic extract of the roots of Broussonetia papyrifera showed extremely high α-glucosidase
inhibitory activity with an IC 50 of around 10 μg/mL. Due to its potency, subsequent …

Soluble phenolics and antioxidant properties of soybean (Glycine max L.) cultivars with varying seed coat colours

…, TJ Ha, YB Lee, WD Seo, JY Kim, HW Ryu… - Journal of Functional …, 2013 - Elsevier
This research was the first to investigate nutritional components, including soluble phenolics
(isoflavones and anthocyanins), protein, oil, and fatty acid as well as antioxidant activities in …

The most abundant polyphenol of soy leaves, coumestrol, displays potent α-glucosidase inhibitory activity

…, JH Lee, MJ Curtis-Long, JW Lee, YS Kim, HW Ryu… - Food chemistry, 2011 - Elsevier
The leaves of soybean (Glycine max) were extracted into four different polar solvents:
ethylacetate, butanol, ethanol and water. The ethylacetate extract (EE) showed the lowest IC 50 …

Potent selective monoamine oxidase B inhibition by maackiain, a pterocarpan from the roots of Sophora flavescens

HW Lee, HW Ryu, MG Kang, D Park, SR Oh… - Bioorganic & Medicinal …, 2016 - Elsevier
Monoamine oxidase (MAO) catalyzes the oxidation of monoamines and its two isoforms,
MAO-A and MAO-B, break down neurotransmitter amines. Of the compounds isolated from the …