Failure in adult spinal deformity surgery: a comprehensive review of current rates, mechanisms, and prevention strategies

JF Burke, JK Scheer, D Lau, MM Safaee, A Lui, S Jha… - Spine, 2022 - journals.lww.com
Study Design. Literature review. Objective. The aim of this review is to summarize recent
literature on adult spinal deformity (ASD) treatment failure as well as prevention strategies …

Impact of surgeon rhBMP-2 cost awareness on complication rates and health system costs for spinal arthrodesis

M McGrath, AH Feroze, D Nistal, E Robinson… - Neurosurgical …, 2021 - thejns.org
OBJECTIVE Recombinant human bone morphogenetic protein–2 (rhBMP-2) is used in
spinal arthrodesis procedures to enhance bony fusion. Research has suggested that it is the …

Use of rhBMP-2 for adult spinal deformity surgery: patterns of usage and changes over the past decade

M Bannwarth, JS Smith, S Bess, EO Klineberg… - Neurosurgical …, 2021 - thejns.org
OBJECTIVE Recombinant human bone morphogenetic protein–2 (rhBMP-2) has been
shown to increase fusion rates; however, cost, limited FDA approval, and possible …

Utilization trends of recombinant human bone morphogenetic protein in the United States

P Kerezoudis, MA Alvi, BA Freedman, A Nassr… - Spine, 2021 - journals.lww.com
Utilization Trends of Recombinant Human Bone Morphogenetic P... : Spine Utilization Trends
of Recombinant Human Bone Morphogenetic Protein in the United States : Spine Log in or …

Recombinant human bone morphogenetic protein–2 use in adult spinal deformity surgery: comparative analysis and healthcare utilization at 24 months' follow-up

N Dietz, M Sharma, M Kelly… - Global Spine …, 2022 - journals.sagepub.com
Study Design: Retrospective cohort study. Objective: Recombinant human bone
morphogenetic protein–2 (rhBMP-2) is used to achieve fusion in adult spinal deformity …

Systemic Diclofenac Sodium Reduces Postoperative rhBMP-2 Induced Neuroinflammation: A Rodent Model Study

GLZ Qiang, SL Jiani, WMR Lam, J Weng, LHK Hua… - Spine, 2023 - journals.lww.com
Study Design: This is a basic science, animal research study. Objective: This study aims to
explore, in rodent models, the effectiveness of systemic nonsteroidal anti-inflammatory drugs …

Utilization trends, cost, and payments for adult spinal deformity surgery in commercial and medicare-insured populations

H Wadhwa, C Leung, M Sklar, CP Ames… - …, 2022 - journals.lww.com
BACKGROUND: Previous studies have characterized utilization rates and cost of adult
spinal deformity (ASD) surgery, but the differences between these factors in commercially …

A BMP/activin a chimera induces posterolateral spine fusion in nonhuman primates at lower concentrations than BMP-2

HJ Seeherman, CG Wilson, EJ Vanderploeg, CT Brown… - JBJS, 2021 - journals.lww.com
Background: Supraphysiologic bone morphogenetic protein (BMP)-2 concentrations are
required to induce spinal fusion. In this study, a BMP-2/BMP-6/activin A chimera (BV-265) …

Trends, payments, and costs associated with BMP use in Medicare beneficiaries undergoing spinal fusion

H Wadhwa, JY Wu, K Malacon, CP Ames, JK Ratliff… - The Spine Journal, 2023 - Elsevier
ABSTRACT BACKGROUND CONTEXT Bone morphogenic protein (BMP) promotes bony
fusion but increases costs. Recent trends in BMP use among Medicare patients have not …

Anterior cervical fusion and rhBMP-2: a prospective study is needed to assess optimal dosing and delivery

TJ Buell, CI Shaffrey - Neurosurgical focus, 2021 - thejns.org
Department of Orthopaedic and Neurological Surgery, Duke University, Durham, North
Carolina SOME prior reports have suggested that the use of recombinant human bone …