Background: The function of the intervertebral disc is structural. Loss of tissue alters
biomechanics, leads to subsequent disc degeneration, and is attributable to discogenic …

Background: A viable disc tissue allograft has been developed to supplement tissue loss
associated with degenerative lumbar disc disease and the development of chronic …

Aim: To explore the effects of viable allogeneic disc tissue supplementation in younger
patients with discogenic chronic low back pain (CLBP). Patients & methods: VAST was a …

Study Design: Review article. Objective: A review of the literature on current strategies
utilized in intervertebral regeneration and repair efforts. Methods: A review of the literature …

Purpose This review aims to explore and summarize the current clinical evidence about the
use of regenerative medicine such as mesenchymal stem cells or platelet-rich plasma in …

Intervertebral disc (IVD) degeneration (IDD) is considered as one of the major causes for low
back pain (LBP). However, conventional surgical approaches for treating LBP do not aim to …

The use of mesenchymal stem cells (MSC) as cell-based therapeutics is by no means a new
concept. Indeed, MSC are currently in clinical trials for a number of autoimmune diseases …

The development of tissue engineering therapies for the intervertebral disc is challenging
due to ambiguities of disease and pain mechanisms in patients, and lack of consensus on …

Objective Possible regenerative treatments for lumbar intervertebral disc degeneration (DD)
are rapidly emerging. There is consensus that the patient that would benefit most has early …

Management of intervertebral disc (IVD) degenerative disease is challenging, as it is
accompanied by irreversible loss of IVD cells. Stem cell transplantation to the disc has …