The effects of topical vancomycin on mesenchymal stem cells: more may not be better

S Chu, N Chen, ABC Dang, AC Kuo… - International Journal of …, 2017 - ijssurgery.com
Background The use of topical vancomycin is increasingly popular in spine surgery. Large
retrospective reviews suggest that topical vancomycin provides a cost-effective decrease in …

[HTML][HTML] The inhibitory effects of vancomycin on rat bone marrow–derived mesenchymal stem cell differentiation

K Hanson, C Isder, K Shogren, AL Mikula, L Lu… - … of Neurosurgery: Spine, 2021 - thejns.org
OBJECTIVE The use of intrawound vancomycin powder in spine surgery has been shown to
decrease the rate of surgical site infections; however, the optimal dose is unknown. High …

Does intrawound application of vancomycin influence bone healing in spinal surgery?

C Eder, S Schenk, J Trifinopoulos, B Külekci… - European Spine …, 2016 - Springer
Purpose Surgical site infections represent a major complication of spinal surgery. The
application of lyophilised vancomycin into the wound is reported to significantly decrease …

Effect of intra‐wound vancomycin for spinal surgery: a systematic review and meta‐analysis

L Xie, J Zhu, M Yang, C Yang, S Luo, Y Xie… - Orthopaedic …, 2017 - Wiley Online Library
Intra‐site prophylactic vancomycin in spine surgery is an effective method of decreasing the
incidence of postsurgical wound infection. However, there are differences in the prophylactic …

Use of intrawound vancomycin powder against postoperative infection after spine surgery

H Takahashi, Y Iida, Y Yokoyama… - Spine Surgery and …, 2018 - jstage.jst.go.jp
Local application of vancomycin has recently become widely used in spine surgery.
However, local application is not included in the indication and has not been approved by …

Vancomycin is toxic to human chondrocytes in vitro

E Röhner, T Zippelius, S Böhle, S Rohe… - Archives of Orthopaedic …, 2021 - Springer
Introduction Vancomycin powder (VP) is a well-established topical antibiotic used in spinal
surgery to prevent surgical site infections. More recently its extension to hip and knee …

[HTML][HTML] Do dose-dependent microbial changes occur during spine surgery as a result of applying intrawound vancomycin powder?: a systematic literature review

L Xie, J Zhu, S Luo, Y Xie, D Pu - Asian Spine Journal, 2018 - ncbi.nlm.nih.gov
We analyzed dose-dependent effects of vancomycin on wound infection bacteria and
investigated the relationship between dose and microbial imbalances in patients treated …

The effect of vancomycin and gentamicin antibiotics on human osteoblast proliferation, metabolic function, and bone mineralization

AM Philp, S Raja, A Philp, MPN Ede, SW Jones - Spine, 2017 - journals.lww.com
Study Design. The present study investigates the effect of vancomycin and gentamicin
antibiotics on primary human osteoblasts. Osteoblasts were incubated with vancomycin …

Selection pressures of vancomycin powder use in spine surgery: a meta-analysis

A Gande, A Rosinski, T Cunningham, N Bhatia… - The Spine Journal, 2019 - Elsevier
BACKGROUND CONTEXT Surgical site infection (SSI) is a serious and costly complication
of spine surgery. Many surgeons apply vancomycin powder to the surgical wound to prevent …

Intraoperative vancomycin use in spinal surgery: single institution experience and microbial trends

GM Ghobrial, V Thakkar, E Andrews, M Lang, A Chitale… - Spine, 2014 - journals.lww.com
Study Design. Retrospective case series. Objective. To demonstrate the microbial trends of
spinal surgical site infections in patients who had previously received crystallized …