Bone graft substitutes is a general term to describe any material used to aid in regeneration
of bone, such as in a fracture, or in promotion of bone, such as in a spine fusion. There is a …

BY HARVINDER S. SANDHU, MD, AND SAFDAR N. KHAN, MD t has been several decades
since Marshall Urist's discovery of osteoinductive activity within demineralized bone protein …

Although great advances have been made in fracture care, treatment failures are not
uncommon. High-energy injuries that result in bone devitalization, or open fractures that are …

The goal in performing spinal fusion techniques is to achieve solid fusion, which will
maximize clinical outcomes. This goal has generated enormous interest in developing bone …

Abstract Purpose of Review Despite the continued growth of spine fusion procedures, the
ideal material for bone regeneration remains unclear. Current bone graft substitutes and …

Bone grafting has been uniquely practiced since the early 1600s. Historically, bone grafting
includes autologous bone, a variety of allograft bone, and synthetic based-materials utilized …

Purpose of review: Spinal fusion often results in high rates of pseudarthrosis and morbidity
related to the harvest of autogenous iliac crest bone graft. For this reason there exists a …

Currently, we are embarking on a chemical revolution in orthopedic medicine. Recent
advances in biotechnology have opened the door to a clearer understanding of ways to …

Spine fusion is a common surgical procedure. With or without instrumentation, the hallmark
of fusion is the biologic union of adjacent vertebrae. To induce this union, autograft is clearly …

Bone graft substitutes span the range of processed allograft bone to synthetic materials and
synthetic-biologic composites. During the past year, studies showed that there is …