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• Safety Evaluation of Intradiscal Delivery of Nucleus Pulposus Allograft for Lumbar Discogenic Pain

  Meredith L. Langhorst, Daniel R. Kendall, Siddardth Umapathy, Amol Soin and Morgan P. Lorio

  • International Journal of Spine Surgery December 2025, 19 (S3) S48;
  • DOI: https://doi.org/10.14444/8808
• Total Joint Replacement of the Lumbar Spine: 12-Month Pain and Functional Outcomes From an Investigational Device Exemption Clinical Trial

  Pierce D. Nunley, J. Alex Sielatycki, S. Craig Humphreys, Scott D. Hodges, Jon E. Block, Domagoj Coric and Jeffrey A. Goldstein

  • International Journal of Spine Surgery December 2025, 19 (S3) S59;
  • DOI: https://doi.org/10.14444/8809
• Billions Spent, Few Saved: Rethinking National Institutes of Health HEAL Initiative in Light of Dopaminergic Alternatives to the Opioid Trap

  Kai-Uwe Lewandrowski, Kenneth Blum, Morgan P. Lorio, Sergio Luis Schmidt and Rossano Kepler Alvim Fiorelli

  • International Journal of Spine Surgery December 2025, 19 (S3) S16;
  • DOI: https://doi.org/10.14444/8804
• Prehabilitation Reimagined as Policy: A Multidimensional Framework to Reduce Pain, Opioid Use, and Surgical Risk

  Kai-Uwe Lewandrowski, Morgan P. Lorio, Igor Elman, Kenneth Blum, Albert Pinhasov, Panayotis K. Thanos, Sergio Luis Schmidt and Rossano Kepler Alvim Fiorelli

  • International Journal of Spine Surgery December 2025, 19 (S3) S30;
  • DOI: https://doi.org/10.14444/8807
• Multifidus Dysfunction and Chronic Low Back Pain: Systematic Review and Meta-analysis of the Supporting Data for Accurate Diagnosis and Successful Treatment Outcomes Associated With Restorative Neurostimulation

  Shay Bess, Virginie Lafage, Morgan Lorio, Bassel G. Diebo and Frank Schwab

  • International Journal of Spine Surgery December 2025, 19 (S3) S67;
  • DOI: https://doi.org/10.14444/8814
• Guest Editorial: Neurogenetics and the Future of Pain: Reclaiming Reward, Function, and Identity

  Kenneth Blum

  • International Journal of Spine Surgery December 2025, 19 (S3) S14;
  • DOI: https://doi.org/10.14444/8806
• Editor’s Introduction—Rethinking Pain: What We Are Treating, What We Are Missing, and Why It Matters

  Morgan P. Lorio

  • International Journal of Spine Surgery December 2025, 19 (S3) S12;
  • DOI: https://doi.org/10.14444/8805
• Comparative Osteoinductive Potential of BMP-2, Bioactive Glass, and Demineralized Bone Matrix: An In Vitro Alkaline Phosphatase Assay Study

  Kingsley R. Chin, Chukwunonso C. Ilogu, Sukanya Chebrolu, William M. Costigan, Erik Spayde, Vito Lore, Douglas P. Beall, Robby Lane, Josue P. Gabriel, Aditya Humad and Jason A. Seale

  • International Journal of Spine Surgery December 2025, 19 (6) 652;
  • DOI: https://doi.org/10.14444/8841
• Metabolic Syndrome as a Risk Factor for Postoperative Complication in Patients Undergoing Spine Surgery: A Systematic Review and Meta-Analysis of More Than 3 Million Cases

  Amir-Mohammad Asgari, Farhad Shaker, Mohammad Taha Pahlevan Fallahy, Sourena Sharifkashani, Alireza Soltani Khaboushan, Dorsa Salabat, César Carballo Cuello, James S. Harrop and Puya Alikhani

  • International Journal of Spine Surgery December 2025, 19 (6) 783;
  • DOI: https://doi.org/10.14444/8813
• What Is the Impact of Single-Photon Emission Computed Tomography on the Management of Degenerative Cervical and Lumbar Spine Disease? A Single-Institution Study

  Michael J. Pompliano, Ali Bagheri, Christopher B. Colwell, Camille R. Nosewicz, Ethan P. Deller, Bahar Shahidi, David C. Sing, James D. Bruffey, Hani Malone, Gregory M. Mundis and Robert K. Eastlack

  • International Journal of Spine Surgery December 2025, 19 (6) 645;
  • DOI: https://doi.org/10.14444/8819

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