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Research ArticleArticles

Vertebroplasty and kyphoplasty for cervical spine metastases: a systematic review and meta-analysis

Rafael De la Garza-Ramos, Mario Benvenutti-Regato and Enrique Caro-Osorio
International Journal of Spine Surgery January 2016, 10 7; DOI: https://doi.org/10.14444/3007
Rafael De la Garza-Ramos
1Tecnológico de Monterrey, School of Medicine and Health Sciences, Monterrey, México
2Institute of Neurology and Neurosurgery, Hospital Zambrano Hellion Tecnológico de Monterrey, Monterrey, México
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Mario Benvenutti-Regato
1Tecnológico de Monterrey, School of Medicine and Health Sciences, Monterrey, México
2Institute of Neurology and Neurosurgery, Hospital Zambrano Hellion Tecnológico de Monterrey, Monterrey, México
3Department of Neurosurgery, Universidad Autónoma de Nuevo León, Monterrey, México
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Enrique Caro-Osorio
1Tecnológico de Monterrey, School of Medicine and Health Sciences, Monterrey, México
2Institute of Neurology and Neurosurgery, Hospital Zambrano Hellion Tecnológico de Monterrey, Monterrey, México
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    Fig. 1

    PRISMA flowchart showing the inclusion/exclusion algorithm. For more information, visit www.prisma-statement.org.

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    Fig. 2

    Distribution of treated cervical vertebrae.

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    Fig. 3

    Approaches to the cervical spine. Top: Overall approaches. Bottom: Approaches by cervical spine level.

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    Fig. 4

    Primary tumor histologies.

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    Fig. 5

    Breast cancer with multiple spinal involvements. A, Lateral radiograph obtained after placement of the needle shows its oblique trajectory and the approach to C2. Note that the needle is placed at the central part of the vertebral body. B, Lateral radiograph, obtained after percutaneous vertebroplasty, shows a satisfactory opacification of the vertebral body but also a cement leakage (arrows). C, Axial CT scan, obtained after percutaneous vertebroplasty, shows cement leakage in the epidural space (short arrow), as well as leakage close to the C1-C2 joint (long arrow). The latter caused a transient occipital neuralgia. (Reprinted with permission, Francisco Mont'Alverne et al. AJNR Am J Neuroradiol 2005;26:1641-1645).

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    Table 1

    Summary of published case series reporting outcomes after vertebroplasty or kyphoplasty for metastatic cervical spine lesions

    StudyNo. Of patientsNo. Vertebral bodiesTreated levelsAgeInjected volumeSuccessPreopVASPostopVASAsymptomaticleakage 6 2ComplicationsFU
    Mont'Alverne et al., 20051212C252.32.780%--61 occipitalneuralgia, 1 stroke;6.9
    Pflugmacher etal., 2006312C3 – C760.41.8-6.32.92None12
    Sun et al., 20101010C2,others62.13100%--43 cases of mild odynophagia10.7
    Masala et al.,20116270C1 – C761.52.597%7.91.72None3
    Anselmetti et al.,20122525C259.3-80%8.11.06None21.8
    Blondel et al.,201266C2 – C563.5--8.02.02None10
    Total 12013559.9 ± 4.02.5 ± 0.589%7.6 ± 0.91.9 ± 0.822 (16%; 95% CI,9.8 – 22.2)5 (4%; 95% CI, 0.5– 7.5%)10.7 ± 6.3
    • Success was defined as being pain-free or experiencing a statistically significant reduction in pain; VAS: visual analog scale; FU: follow-up.

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1 Jan 2016
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Vertebroplasty and kyphoplasty for cervical spine metastases: a systematic review and meta-analysis
Rafael De la Garza-Ramos, Mario Benvenutti-Regato, Enrique Caro-Osorio
International Journal of Spine Surgery Jan 2016, 10 7; DOI: 10.14444/3007

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Vertebroplasty and kyphoplasty for cervical spine metastases: a systematic review and meta-analysis
Rafael De la Garza-Ramos, Mario Benvenutti-Regato, Enrique Caro-Osorio
International Journal of Spine Surgery Jan 2016, 10 7; DOI: 10.14444/3007
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Keywords

  • cervical metastases
  • vertebroplasty
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  • systematic review
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