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Research ArticleTumor

Metastasectomy and Targeted Therapy for Patients With Spinal Metastases of Renal Cell Carcinoma

DMITRII PTASHNIKOV, NIKITA ZABOROVSKII, STANISLAV KOSTRICKII, DMITRII MIKAYLOV, SERGEI MASEVNIN, OLEG SMEKALENKOV and IRAKLI KUPARADZE
International Journal of Spine Surgery December 2020, 14 (6) 982-988; DOI: https://doi.org/10.14444/7147
DMITRII PTASHNIKOV
1Spine Surgery and Oncology Service, R.R. Vreden Russian Research Institute of Traumatology and Orthopedics, Saint-Petersburg, Russia
3North-Western State Medical University named after I.I. Mechnikov, Saint-Petersburg, Russia
MD, PHD, D OF SC
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NIKITA ZABOROVSKII
1Spine Surgery and Oncology Service, R.R. Vreden Russian Research Institute of Traumatology and Orthopedics, Saint-Petersburg, Russia
MD, PHD
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STANISLAV KOSTRICKII
2Urology Department, Moscow Oncology Hospital No. 62, Moscow, Russia
MD
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DMITRII MIKAYLOV
1Spine Surgery and Oncology Service, R.R. Vreden Russian Research Institute of Traumatology and Orthopedics, Saint-Petersburg, Russia
MD, PHD
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SERGEI MASEVNIN
1Spine Surgery and Oncology Service, R.R. Vreden Russian Research Institute of Traumatology and Orthopedics, Saint-Petersburg, Russia
MD
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OLEG SMEKALENKOV
1Spine Surgery and Oncology Service, R.R. Vreden Russian Research Institute of Traumatology and Orthopedics, Saint-Petersburg, Russia
MD, PHD
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IRAKLI KUPARADZE
3North-Western State Medical University named after I.I. Mechnikov, Saint-Petersburg, Russia
MD
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    Figure 1

    Neurological status of patients by Frankel scale.

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    Figure 2

    Kaplan-Meier survival curves with confidence intervals (CIs) stratified by surgery. The median overall survival of patients with decompression was 22 months (95% CI = 16–32), 3- and 5-year survival rates 30.7% and 11.2%, respectively. The median overall survival of patients with metastasectomy was 22 months (95% CI = 18–30), 3- and 5-year survival rates 28.2% and 12.8%, respectively.

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    Figure 3

    Kaplan-Meier survival curves with confidence intervals (CIs) stratified by adjuvant therapy. The median overall survival of patients with cytokine therapy was 18 months (95% CI = 16–24), 3- and 5-year survival rates 21% and 6.6%, respectively. The median overall survival of patients with targeted therapy was 38 months (95% CI = 27–61), 3- and 5-year survival rates 53.6% and 26.8%, respectively.

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    Figure 4

    Kaplan-Meier survival curves with confidence intervals (CIs) stratified by surgery. The 3- and 5-year local progression-free survival rare in patients with decompression was 76.4%. The 3- and 5-year local progression-free survival rates in patients with metastasectomy were 90.6% and 82.4%, respectively.

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    Figure 5

    Kaplan-Meier survival curves with confidence intervals (CIs) stratified by adjuvant therapy. The 3- and 5-year local progression-free survival rates in patients with cytokine therapy were 77.4% and 72.9%, respectively. The 3- and 5-year local progression-free survival rate in patients with targeted therapy was 95.8%.

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International Journal of Spine Surgery
Vol. 14, Issue 6
1 Dec 2020
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Metastasectomy and Targeted Therapy for Patients With Spinal Metastases of Renal Cell Carcinoma
DMITRII PTASHNIKOV, NIKITA ZABOROVSKII, STANISLAV KOSTRICKII, DMITRII MIKAYLOV, SERGEI MASEVNIN, OLEG SMEKALENKOV, IRAKLI KUPARADZE
International Journal of Spine Surgery Dec 2020, 14 (6) 982-988; DOI: 10.14444/7147

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Metastasectomy and Targeted Therapy for Patients With Spinal Metastases of Renal Cell Carcinoma
DMITRII PTASHNIKOV, NIKITA ZABOROVSKII, STANISLAV KOSTRICKII, DMITRII MIKAYLOV, SERGEI MASEVNIN, OLEG SMEKALENKOV, IRAKLI KUPARADZE
International Journal of Spine Surgery Dec 2020, 14 (6) 982-988; DOI: 10.14444/7147
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