Skip to main content

Main menu

  • Home
  • Content
    • Current Issue
    • Advance Online Publication
    • Archive
  • About Us
    • About ISASS
    • About the Journal
    • Author Instructions
    • Editorial Board
    • Reviewer Guidelines & Publication Criteria
  • More
    • Advertise
    • Subscribe
    • Alerts
    • Feedback
  • Join Us
  • Reprints & Permissions
  • Sponsored Content
  • Other Publications
    • ijss

User menu

  • My alerts

Search

  • Advanced search
International Journal of Spine Surgery
  • My alerts
International Journal of Spine Surgery

Advanced Search

  • Home
  • Content
    • Current Issue
    • Advance Online Publication
    • Archive
  • About Us
    • About ISASS
    • About the Journal
    • Author Instructions
    • Editorial Board
    • Reviewer Guidelines & Publication Criteria
  • More
    • Advertise
    • Subscribe
    • Alerts
    • Feedback
  • Join Us
  • Reprints & Permissions
  • Sponsored Content
  • Follow ijss on Twitter
  • Visit ijss on Facebook
Research ArticleDisc Biology

Stem Cells and Intervertebral Disc Regeneration Overview—What They Can and Can't Do

Gianluca Vadalà, Luca Ambrosio, Fabrizio Russo, Rocco Papalia and Vincenzo Denaro
International Journal of Spine Surgery April 2021, 15 (s1) 40-53; DOI: https://doi.org/10.14444/8054
Gianluca Vadalà
Department of Orthopaedic and Trauma Surgery, Campus Bio-Medico University of Rome, Rome, Italy
MD, PHD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Luca Ambrosio
Department of Orthopaedic and Trauma Surgery, Campus Bio-Medico University of Rome, Rome, Italy
MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Fabrizio Russo
Department of Orthopaedic and Trauma Surgery, Campus Bio-Medico University of Rome, Rome, Italy
MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Rocco Papalia
Department of Orthopaedic and Trauma Surgery, Campus Bio-Medico University of Rome, Rome, Italy
MD, PHD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Vincenzo Denaro
Department of Orthopaedic and Trauma Surgery, Campus Bio-Medico University of Rome, Rome, Italy
MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

Article Figures & Data

Figures

  • Tables
  • Figure 1
    • Download figure
    • Open in new tab
    • Download powerpoint
    Figure 1

    The main effects of stem cells following transplantation into the intervertebral disc. IVD, intervertebral disc; ECM, extracellular matrix; TNFα, tumor necrosis factor-α; IL, interleukin; IFN, interferon; MMP, matrix metalloproteinase. Created with BioRender.com.

Tables

  • Figures
  • Table 1
  • Table 2
PreviousNext
Back to top

In this issue

International Journal of Spine Surgery: 15 (s1)
International Journal of Spine Surgery
Vol. 15, Issue s1
1 Apr 2021
  • Table of Contents
  • Index by author

Print
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on International Journal of Spine Surgery.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Stem Cells and Intervertebral Disc Regeneration Overview—What They Can and Can't Do
(Your Name) has sent you a message from International Journal of Spine Surgery
(Your Name) thought you would like to see the International Journal of Spine Surgery web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Stem Cells and Intervertebral Disc Regeneration Overview—What They Can and Can't Do
Gianluca Vadalà, Luca Ambrosio, Fabrizio Russo, Rocco Papalia, Vincenzo Denaro
International Journal of Spine Surgery Apr 2021, 15 (s1) 40-53; DOI: 10.14444/8054

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Stem Cells and Intervertebral Disc Regeneration Overview—What They Can and Can't Do
Gianluca Vadalà, Luca Ambrosio, Fabrizio Russo, Rocco Papalia, Vincenzo Denaro
International Journal of Spine Surgery Apr 2021, 15 (s1) 40-53; DOI: 10.14444/8054
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • ABSTRACT
    • INTRODUCTION
    • THE RATIONALE OF A STEM CELL–BASED THERAPY FOR IDD
    • THE EFFECT OF STEM CELLS IN THE DEGENERATIVE IVD ENVIRONMENT
    • CURRENT CLINICAL EVIDENCE
    • MAIN LIMITATIONS AND FUTURE PERSPECTIVES
    • CONCLUSION
    • Footnotes
    • REFERENCES
  • Figures & Data
  • Info & Metrics
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • Single cell RNA sequencing reveals shifts in cell maturity and function of endogenous and infiltrating cell types in response to acute intervertebral disc injury
  • Allogenic bone marrow-derived mesenchymal stromal cell-based therapy for patients with chronic low back pain: a prospective, multicentre, randomised placebo controlled trial (RESPINE study)
  • Google Scholar

More in this TOC Section

  • Pathomechanism and Biomechanics of Degenerative Disc Disease: Features of Healthy and Degenerated Discs
  • Risks of Intradiscal Orthobiologic Injections: A Review of the Literature and Case Series Presentation
Show more Disc Biology

Similar Articles

Keywords

  • intervertebral disc degeneration
  • stem cell
  • disc regeneration
  • intradiscal injection
  • mesenchymal stem cells

Content

  • Current Issue
  • Latest Content
  • Archive

More Information

  • About IJSS
  • About ISASS
  • Privacy Policy

More

  • Subscribe
  • Alerts
  • Feedback

Other Services

  • Author Instructions
  • Join ISASS
  • Reprints & Permissions

© 2025 International Journal of Spine Surgery

International Journal of Spine Surgery Online ISSN: 2211-4599

Powered by HighWire