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Research ArticleCervical Spine

Anterior vs Posterior Approach in Multilevel Cervical Spondylotic Myelopathy: A Nationwide Propensity-Matched Analysis of Complications, Outcomes, and Narcotic Use

Ravi S. Nunna, Syed Khalid, Ryan G. Chiu, Rown Parola, Richard G. Fessler, Owoicho Adogwa and Ankit I. Mehta
International Journal of Spine Surgery February 2022, 16 (1) 88-94; DOI: https://doi.org/10.14444/8198
Ravi S. Nunna
1 Department of Neurosurgery, Swedish Medical Center, Seattle, WA, USA
MD
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Syed Khalid
2 Department of Surgery, Rush University Medical Center, Chicago, IL, USA
MD
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Ryan G. Chiu
3 Department of Neurosurgery, University of Illinois-Chicago Medical Center, Chicago, IL, USA
BS
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Rown Parola
3 Department of Neurosurgery, University of Illinois-Chicago Medical Center, Chicago, IL, USA
BS
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Richard G. Fessler
4 Department of Neurosurgery, Rush University Medical Center, Chicago, IL, USA
MD, PhD
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Owoicho Adogwa
5 Department of Neurosurgery, University of Texas Southwestern Medical Center, Dallas, TX, USA
MD, MPH
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Ankit I. Mehta
3 Department of Neurosurgery, University of Illinois-Chicago Medical Center, Chicago, IL, USA
MD
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    Table 1

    Baseline characteristics of propensity score–matched cohorts by treatment group (N = 12,248).

    CharacteristicsTotal (N = 12,248)PCDF (N = 6124)ACDF (N = 6124) P
    Age, y1.0
     ≤644650 (38.0)2351 (38.4)2299 (37.5)
     65–692826 (23.1)1424 (23.3)1402 (22.9)
     70–742552 (20.8)1294 (21.1)1258 (20.5)
     75–791628 (13.3)829 (13.5)799 (13.0)
     80–84744 (6.1)378 (6.2)366 (6.0)
     ≥85187 (1.5)94 (1.5)93 (1.5)
    Sex1.0
     Men,6962 (56.8)3481 (56.8)3481(56.8)
     Women5466 (44.6)2733 (44.6)2733 (44.6)
    Race1.0
     White8500 (69.4)4250 (69.4)4250 (69.4)
     Black1508 (12.3)754 (12.3)754 (12.3)
     Hispanic62 (0.5)31 (0.5)31 (0.5)
     Other68 (0.6)34 (0.6)34 (0.6)
     Unknown2266 (18.5)1133 (18.5)1133 (18.5)
    Comorbidities
     Smoking status2805 (22.9)1458 (23.8)1347 (22.0)0.02
     Depression4217 (34.4)2085 (34.0)2132 (34.8)0.37
     Anxiety3665 (29.9)1837 (30.0)1828 (29.9)0.86
     Chronic kidney disease3280 (26.8)1694 (27.7)1586 (25.9)0.03
     Chronic lung disease1403 (11.5)679 (11.1)724 (11.8)0.20
     Congestive heart failure1785 (14.6)960 (15.7)825 (13.5)<0.01
     Coagulopathy929 (7.6)502 (8.2)427 (7.0)0.01
     Diabetes mellitus4906 (40.1)2374 (38.8)2532 (41.3)<0.01
     Alcohol abuse684 (5.6)395 (6.5)289 (4.7)<0.01
     Hypertension9846 (80.4)4900 (80.0)4946 (80.8)0.30
     Obesity3226 (26.3)1546 (25.2)1680 (27.4)0.01
     Hyperlipidemia8909 (72.7)4342 (70.9)4567 (74.6)<0.01
    Hospital region
     Midwest2815 (23.0)1572 (25.7)1243 (20.3)<0.01
     Northeast241 (2.0)141 (2.3)100 (1.6)<0.01
     South8208 (67.0)3870 (63.2)4332 (70.7)<0.01
     West1175 (9.6)636 (10.4)539 (8.8)<0.01
    • Data presented as n (%).

    • ACDF, anterior discectomy and fusion; PCDF, posterior decompression and fusion.

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    Table 2

    Outcomes of propensity score–matched cohorts by treatment group (N = 12,248).

    PCDF (N = 6124)ACDF (N = 6124)OR (95% CI) P
    Inpatient complications
     Coma, n (%)34 (0.6)27 (0.4)1.26 (0.75–1.77)0.37
     Death0 (0)0 (0)NA1.00
     Hematoma formation94 (1.5)84 (1.4)1.12 (0.83–1.51)0.45
     Dysphagia100 (1.6)163 (2.7)0.61 (0.36–0.86)0.0001
     UTI701 (11.4)304 (5.0)2.47 (2.34–2.61)<0.0001
     DVT261 (4.3)140 (2.3)1.90 (1.69–2.11)<0.0001
     PE113 (1.8)65 (1.1)1.75 (1.45–2.06)0.0003
    30-Day complications
     Stroke255 (4.2)154 (2.5)1.68 (1.48–1.89)<0.0001
     Wound dehiscence164 (2.7)30 (0.5)5.59 (5.20–5.98)<0.0001
     Surgical site infection289 (4.7)63 (1.0)4.76 (4.49–5.04)<0.0001
     Wound revision surgery72 (1.2)24 (0.4)3.02 (2.56–3.49)<0.0001
     All-cause readmission1253 (20.5)694 (11.3)2.01 (1.91–2.11)<0.0001
    1-Year outcomes
     Pseudarthrosis288 (4.7)122 (2.0)2.43 (1.96–3.01)<0.0001
     Revision or extension of index surgery485 (7.9)218 (3.6)2.33 (2.17–2.49)<0.0001
     Additional anterior or posterior fusion265 (4.3)a429 (7.0)b0.60 (0.44–0.76)<0.0001
    • Data presented as n (%) unless otherwise indicated.

    • aAdditional ACDF surgery.

    • bAdditional PCDF surgery.

    • ACDF, anterior discectomy and fusion; DVT, deep vein thrombosis; NA, not applicable.; PCDF, posterior decompression and fusion; PE, pulmonary embolism; UTI, urinary tract infection.

    • View popup
    Table 3

    Narcotic use of propensity score-matched cohorts by treatment group (N = 12,248).

    PCDF (N = 6124)ACDF (N = 6124)OR (95% CI) P
    Frequency of narcotic use
     30-day narcotic use, n (%)4208 (68.7)4338 (70.8)0.90 (0.83–0.98)0.01
     60-day narcotic use, n (%)3990 (65.2)4185 (68.3)0.79 (0.79–0.94)0.0002
     90-day narcotic use, n (%)3818 (62.3)4055 (66.2)0.84 (0.77–0.92)<0.0001
     120-day narcotic use, n (%)3674 (60.0)3943 (64.4)0.83 (0.76–0.90)<0.0001
    Level of narcotic use
     30-day mean MME, mg1584.251384.641.19 (1.11–1.28)<0.0001
     60-day mean MME, mg1601.761395.591.20 (1.12–1.28)<0.0001
     90-day mean MME, mg1614.861402.071.21 (1.12–1.29)<0.0001
     120-day mean MME, mg1624.521408.091.21 (1.13–1.29)<0.0001
    • Data presented as n (%) unless otherwise indicated.

    • ACDF, anterior discectomy and fusion; CSM, cervical spondylotic myelopathy; MME, morphine milligram equivalent; PCDF, posterior decompression and fusion.

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Anterior vs Posterior Approach in Multilevel Cervical Spondylotic Myelopathy: A Nationwide Propensity-Matched Analysis of Complications, Outcomes, and Narcotic Use
Ravi S. Nunna, Syed Khalid, Ryan G. Chiu, Rown Parola, Richard G. Fessler, Owoicho Adogwa, Ankit I. Mehta
International Journal of Spine Surgery Feb 2022, 16 (1) 88-94; DOI: 10.14444/8198

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Anterior vs Posterior Approach in Multilevel Cervical Spondylotic Myelopathy: A Nationwide Propensity-Matched Analysis of Complications, Outcomes, and Narcotic Use
Ravi S. Nunna, Syed Khalid, Ryan G. Chiu, Rown Parola, Richard G. Fessler, Owoicho Adogwa, Ankit I. Mehta
International Journal of Spine Surgery Feb 2022, 16 (1) 88-94; DOI: 10.14444/8198
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Keywords

  • cervical
  • spondylotic
  • myelopathy
  • Anterior
  • posterior
  • ACDF
  • PCDF
  • CSM
  • degenerative
  • spondylosis

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