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Research ArticleEndoscopic Minimally Invasive Surgery

Comparison of Postoperative Epidural Hematoma Formation Between Biportal Endoscopic Spine Surgery and Conventional Microscopic Surgery: A Randomized Controlled Trial

Dae-Woong Ham, Jeuk Lee, Byung-Taek Kwon, Yisack Yoo, Sang-Min Park and Kwang-Sup Song
International Journal of Spine Surgery October 2024, 18 (5) 533-539; DOI: https://doi.org/10.14444/8578
Dae-Woong Ham
1 Department of Orthopedic Surgery, Chung-Ang University Hospital, College of Medicine, Chung-Ang University, Seoul, South Korea
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Jeuk Lee
1 Department of Orthopedic Surgery, Chung-Ang University Hospital, College of Medicine, Chung-Ang University, Seoul, South Korea
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Byung-Taek Kwon
2 Department of Orthopedic Surgery, Chung-Ang University Gwang Myeong Hospital, Gwangmyeongsi, South Korea
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Yisack Yoo
1 Department of Orthopedic Surgery, Chung-Ang University Hospital, College of Medicine, Chung-Ang University, Seoul, South Korea
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Sang-Min Park
3 Spine Center and Department of Orthopedic Surgery, Seoul National University College of Medicine and Seoul National University Bundang Hospital, Seongnamsi, South Korea
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Kwang-Sup Song
1 Department of Orthopedic Surgery, Chung-Ang University Hospital, College of Medicine, Chung-Ang University, Seoul, South Korea
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  • For correspondence: ksong70@cau.ac.kr
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  • Figure 1
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    Figure 1

    Measuring the cross-sectional area (CSA) of the dura sac and epidural hematoma on magnetic resonance imaging. (A and B) Pre- and postoperative dura sac CSA was measured (yellow line). (C) The CSA of the postoperative epidural hematoma was measured (yellow dotted line).

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    Figure 2

    Comparison of clinical outcome measures between conventional and biportal endoscopic spine surgery (BESS) groups. Both groups showed improvements in clinical outcome measures up to 1 year postoperatively, with no significant differences observed between the groups at any time point. Error bars represent the SD of the mean values.

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    Figure 3

    Comparison of pre- and postoperative cross-sectional areas of the dura sac between the conventional and biportal endoscopic spine surgery (BESS) groups, including changes in the dura sac and the epidural hematoma. *Statistically significant at P = 0.033.

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    Table 1

    Baseline characteristics of included patients by study group.

    CharacteristicConventional (n = 24)BESS (n = 22)Total (N = 46) P
    Age, y, mean ± SD60.2 ± 12.863.0 ± 10.261.5 ± 11.60.405
    Sex, man, n (%)15 (62.5)12 (54.5)27 (58.7)0.804
    BMI, mean ± SD25.3 ± 3.525.6 ± 2.825.5 ± 3.10.765
    Diagnosis, n (%)0.725
     HIVD13 (54.2)14 (63.6)27 (58.7) 
     Stenosis11 (45.8)8 (36.4)19 (41.3)
    Operation level, n (%)0.156
     L2–L30 (0.0)1 (4.5)1 (2.2) 
     L3–L44 (16.7)1 (4.5)5 (10.9)
     L4–L518 (75.0)14 (63.6)32 (69.6)
     L5–S12 (8.3)6 (27.3)8 (17.4)
    Drainage, cc, mean ± SD38.8 ± 31.553.2 ± 24.445.5 ± 29.00.096
    Drain removal date, d, n (%)0.569
     01 (4.2)0 (0.0)1 (2.2) 
     15 (20.8)6 (28.6)11 (24.4) 
     216 (66.7)15 (71.4)31 (68.9) 
     31 (4.2)0 (0.0)1 (2.2) 
     41 (4.2)0 (0.0)1 (2.2) 
    Drain removal date, mean ± SD1.8 ± 0.81.7 ± 0.51.8 ± 0.60.525
    Neurological deficit, n (%)1 (4.2)0 (0.0)1 (2.2)>0.99
    Comorbidity, n (%)
     Hypertension8 (33.3)8 (38.1)16 (35.6)0.983
     Diabetes mellitus2 (8.3)1 (4.8)3 (6.7)>0.99
    ODI
     Preoperative0.19 ± 0.100.23 ± 0.090.21 ± 0.100.174
     Postoperative 3 mo0.07 ± 0.060.05 ± 0.040.06 ± 0.050.324
     Postoperative 6 mo0.05 ± 0.080.05 ± 0.070.05 ± 0.070.955
     Postoperative 12 mo0.03 ± 0.070.02 ± 0.050.02 ± 0.060.711
    Back pain VAS
     Preoperative4.88 ± 2.614.24 ± 2.454.58 ± 2.530.405
     Postoperative 3 mo1.78 ± 1.171.52 ± 1.291.66 ± 1.220.488
     Postoperative 6 mo1.35 ± 1.701.38 ± 1.561.36 ± 1.620.947
     Postoperative 12 mo0.61 ± 1.530.33 ± 0.800.48 ± 1.230.454
    Leg pain VAS
     Preoperative6.17 ± 2.306.36 ± 2.346.26 ± 2.290.775
     Postoperative 3 mo1.50 ± 1.291.32 ± 0.991.41 ± 1.150.597
     Postoperative 6 mo1.00 ± 1.221.45 ± 1.991.22 ± 1.630.362
     Postoperative 12 mo0.79 ± 1.930.32 ± 0.650.57 ± 1.470.267
    • Abbreviations: BESS, biportal endoscopic spine surgery; BMI, body mass index; HIVD, herniated intervertebral disc; ODI, Oswestry Disability Index; VAS, visual analog scale.

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    Table 2

    Laboratory examination findings by study group.

    Outcome MeasureConventional (n = 24)BESS (n = 22)Total (N = 46) P
    Coagulation battery
     Prothrombin time, s10.8 ± 0.611.0 ± 0.510.9 ± 0.60.153
     Prothrombin time (INR)1.0 ± 0.11.0 ± 0.01.0 ± 0.00.123
     aPTT, s31.6 ± 4.230.9 ± 2.731.3 ± 3.60.522
    Albumin4.4 ± 0.34.4 ± 0.34.4 ± 0.30.709
    CPK, IU/L
     Preoperative118.0 ± 95.7103.7 ± 78.2111.2 ± 87.10.592
     Postoperative142.4 ± 95.4109.2 ± 79.9126.6 ± 88.90.221
    CRP, mg/L
     Preoperative2.1 ± 3.22.6 ± 7.42.3 ± 5.60.782
     Immediate postoperative2.1 ± 3.81.0 ± 0.81.6 ± 2.90.190
    Hemoglobin, g/dL
     Preoperative14.1 ± 1.413.8 ± 1.114.0 ± 1.30.552
     Immediate postoperative13.5 ± 1.313.0 ± 1.213.3 ± 1.20.155
     Postoperative day 112.9 ± 1.212.3 ± 1.112.6 ± 1.20.088
    • Abbreviations: aPTT, activated partial thromboplastin clotting time; BESS, biportal endoscopic spine surgery; CPK, creatine phosphokinase; CRP, C-reactive protein.

    • Note: All values presented as mean ± SD.

    • View popup
    Table 3

    CSA of pre- and postoperative magnetic resonance imaging.

    CSA, cm2 Conventional (n = 24)BESS (n = 22)Total (N = 46) P
    Preoperative dura sac0.75 ± 0.370.69 ± 0.330.72 ± 0.350.644
    Postoperative dura sac0.97 ± 0.441.09 ± 0.501.03 ± 0.470.412
    ΔCSA of dura sac0.22 ± 0.470.40 ± 0.480.31 ± 0.480.253
    Hematoma0.17 ± 0.150.36 ± 0.340.26 ± 0.28 0.033
    • Abbreviations: BESS, biportal endoscopic spine surgery; CSA, cross-sectional area.

    • Note: All values presented as mean ± SD.

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International Journal of Spine Surgery
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1 Oct 2024
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Comparison of Postoperative Epidural Hematoma Formation Between Biportal Endoscopic Spine Surgery and Conventional Microscopic Surgery: A Randomized Controlled Trial
Dae-Woong Ham, Jeuk Lee, Byung-Taek Kwon, Yisack Yoo, Sang-Min Park, Kwang-Sup Song
International Journal of Spine Surgery Oct 2024, 18 (5) 533-539; DOI: 10.14444/8578

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Comparison of Postoperative Epidural Hematoma Formation Between Biportal Endoscopic Spine Surgery and Conventional Microscopic Surgery: A Randomized Controlled Trial
Dae-Woong Ham, Jeuk Lee, Byung-Taek Kwon, Yisack Yoo, Sang-Min Park, Kwang-Sup Song
International Journal of Spine Surgery Oct 2024, 18 (5) 533-539; DOI: 10.14444/8578
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