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Research ArticleNew Technology

High Uptake Detection for Spinal Degenerative Changes: A Comparison Between Bone Scintigraphy and Single Photon Emission Computed Tomography Combined With High-Resolution Computed Tomography

Mara Ioana Dimitriu, Robin Brugger, Nikki Rommers, Martin Jaeger, Victoria Schimmelpenning and Helena Milavec
International Journal of Spine Surgery April 2025, 19 (2) 139-144; DOI: https://doi.org/10.14444/8729
Mara Ioana Dimitriu
1 Department of Orthopedic Surgery and Traumatology, Spine Unit, Aarau Cantonal Hospital, Aarau, Switzerland
Pʀᴀᴄᴛ. Mᴇᴅ
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  • For correspondence: Maraioana.dimitriu@yahoo.com
Robin Brugger
1 Department of Orthopedic Surgery and Traumatology, Spine Unit, Aarau Cantonal Hospital, Aarau, Switzerland
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Nikki Rommers
2 Department of Clinical Research, University of Basel, University Hospital Basel, Basel, Switzerland
PhD
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Martin Jaeger
1 Department of Orthopedic Surgery and Traumatology, Spine Unit, Aarau Cantonal Hospital, Aarau, Switzerland
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Victoria Schimmelpenning
1 Department of Orthopedic Surgery and Traumatology, Spine Unit, Aarau Cantonal Hospital, Aarau, Switzerland
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Helena Milavec
1 Department of Orthopedic Surgery and Traumatology, Spine Unit, Aarau Cantonal Hospital, Aarau, Switzerland
3 Department of Orthopedic Surgery and Traumatology, University Hospital Bern, Inselspital, University of Bern, Bern, Switzerland
4 Spine Center, Schulthess Klinik, Zurich, Switzerland
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    Figure 1

    Forty-five-year-old male patient with pain in the thoracic spine region. The bone scan (bottom left) and the single photon emission computed tomography (CT) combined with high-resolution CT (top images) show high uptake in the facet joints of T7 to T10 bilaterally. The native CT (bottom right) reveals facet joint osteoarthritis.

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    Figure 2

    Seventy-eight-year-old female patient with lower back pain. The bone scan (top image) and the single photon emission computed tomography (CT) combined with high-resolution CT (bottom left) show high uptake in the right sacroiliac joint (SIJ). The native CT (bottom right) reveals SIJ osteoarthritis.

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    Figure 3

    The diagrams illustrate the prevalence of the high uptake in the specific regions of interest in bone scan vs SPECT/CT. Abbreviations: CT, computed tomography; SPECT/CT, single photon emission computed tomography combined with high-resolution CT.

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    Table

    Sensitivity, specificity, and diagnostic accuracy of BS compared with SPECT.

    VariableEstimate95% CI
    Cervical spine (n = 48)
     Sensitivity (%)41.5(27.8, 56.6)
     Specificity (%)100.0(64.6, 100.0)
     Diagnostic accuracy (%)50.0(36.4, 63.6)
    Thoracic spine (n = 34)
     Sensitivity (%)50.0(29.0, 71.0)
     Specificity (%)100.0(80.6, 100.0)
     Diagnostic accuracy (%)73.5(56.9, 85.4)
    Lumbar spine (n = 91)
     Sensitivity (%)72.9(61.5, 81.9)
     Specificity (%)100.0(84.5, 100.0)
     Diagnostic accuracy (%)79.1(69.7, 86.2)
    Sacroiliac joint (n = 91)
     Sensitivity (%)38.2(23.9, 55.0)
     Specificity (%)96.5(88.1, 99.0)
     Diagnostic accuracy (%)74.7(64.9, 82.5)
    • Abbreviations: BS, bone scan; SPECT, single photon emission computed tomography.

    • Note: Elevated uptakes identified on BS were consistently observed on SPECT, but only about half of the uptakes detected on SPECT were visible on BS alone.

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International Journal of Spine Surgery
Vol. 19, Issue 2
1 Apr 2025
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High Uptake Detection for Spinal Degenerative Changes: A Comparison Between Bone Scintigraphy and Single Photon Emission Computed Tomography Combined With High-Resolution Computed Tomography
Mara Ioana Dimitriu, Robin Brugger, Nikki Rommers, Martin Jaeger, Victoria Schimmelpenning, Helena Milavec
International Journal of Spine Surgery Apr 2025, 19 (2) 139-144; DOI: 10.14444/8729

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High Uptake Detection for Spinal Degenerative Changes: A Comparison Between Bone Scintigraphy and Single Photon Emission Computed Tomography Combined With High-Resolution Computed Tomography
Mara Ioana Dimitriu, Robin Brugger, Nikki Rommers, Martin Jaeger, Victoria Schimmelpenning, Helena Milavec
International Journal of Spine Surgery Apr 2025, 19 (2) 139-144; DOI: 10.14444/8729
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Keywords

  • nuclear imaging
  • neck pain
  • back pain
  • SPECT/CT
  • bone scan
  • diagnostic performance
  • prevalence
  • degenerative spine
  • sacroiliac joint

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