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Research ArticleArticle
Open Access

Validation and Analysis of a Multi-site MIS Prospective Registry Through Sub-analysis of an MIS TLIF Subgroup

Joseph A. Sclafani, Kamshad Raiszadeh, Ramin Raiszadeh, Paul Kim, Todd Doerr, Farhan Siddiqi, Ivan LaMotta, Paul Park, Cary Templin, Sandeep Gill, Kevin Liang and Choll W. Kim
International Journal of Spine Surgery January 2014, 8 4; DOI: https://doi.org/10.14444/1004
Joseph A. Sclafani
1Spine Institute of San Diego, Minimally Invasive Spine Center of Excellence
MD
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Kamshad Raiszadeh
1Spine Institute of San Diego, Minimally Invasive Spine Center of Excellence
MD
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Ramin Raiszadeh
1Spine Institute of San Diego, Minimally Invasive Spine Center of Excellence
MD
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Paul Kim
1Spine Institute of San Diego, Minimally Invasive Spine Center of Excellence
MD
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Todd Doerr
2Spine & Orthopedic Specialists, PLLC
MD
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Farhan Siddiqi
3Trinity Spine Center
MD
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Ivan LaMotta
4Midland Orthopaedics
MD
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Paul Park
5University of Michigan
MD
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Cary Templin
6Hinsdale Orthopaedics
MD
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Sandeep Gill
7Milestone Research Organization
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Kevin Liang
7Milestone Research Organization
PhD
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Choll W. Kim
1Spine Institute of San Diego, Minimally Invasive Spine Center of Excellence
MD, PhD
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Article Figures & Data

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  • Fig. 1
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    Fig. 1

    MIS TLIF Subgroup: Improvement in Walking and Employment Disability. A significant improvement in walking ability (analyzed from ODI question #4) and employment tolerance (analyzed from ODI question #8) was observed starting at the 6 week post-operative assessment.

  • Fig. 2
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    Fig. 2

    MIS TLIF Subgroup Oswesty Disability Index Outcome Segmented by Pre-operative Disability. All subgroups were observed to have a significant improvement in Oswestry Disability Index scores at the 1 year post-operative assessment. However, the post-operative time needed to attain initial significant improvement in ODI was different for every subgroup. Patients with high pre-operative disability (>50) reported a significant improvement starting at the 6 week post-op time point. Patients with a lower pre-operative disability index score (< 50) reached significant improvement in ODI score starting 3 months post-op.

  • Fig. 3A and 3B
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    Fig. 3A and 3B

    Survey Question Completion Rate. Individual question response rate was performed for each of the questions asked to patients (1A) and to the operating surgeon (1B) over a 2 year study period. A response rate less than 50% was observed for 78 patient-directed questions and 24 surgeon-directed questions.

  • Fig. 4
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    Fig. 4

    Algorithm detailing correspondence method used to obtain missing 1 year post-operative follow-up information. Email based surveys were sent to the remaining patients with missing information without any additional form acquisition.

  • Figure5
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Tables

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    Table 1

    Patient Enrollment by Procedure.

    n
    Total enrolled patients478
    Procedure
    MIS Hemilaminectomy118
    MIS TLIF98
    Transforaminal Endoscopic Foraminotomy & Discectomy86
    MIS ALIF40
    MIS Microdiscectomy31
    MIS Lateral Lumbar Interbody Fusion22
    MIS ACDF18
    Other65
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    Table 2

    Clinical Outcomes for the Overall Registry Population.

    Preoperative 1 Year Postoperative Paired t-test (p)
    ODI47.1 ± 16.9 (n = 98)28.8 ± 21.2 (n = 84)0.001
    VAS Back6.5 ± 2.6 (n = 98)3.2 ± 2.7 (n = 84)0.001
    VAS Affected Leg5.3 ± 2.8 (n = 98)1.7 ± 2.6 (n = 84)0.001
    Preoperative 6 Months Postoperative Paired t-test (p)
    SF-12 MCS42.0 ± 15.5 (n = 282)48.2 ± 17.4 (n = 77)0.05
    SF-12 PCS28.2 ± 9.8 (n = 282)37.0 ± 15.3 (n = 77)0.001
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    Table 3

    MIS TLIF Subgroup Demographic Data. All surgical indications for MIS TLIF are included in the MIS Registry on a level-by level basis.

    n
    Total MIS TLIF Patients 98
    Median Age at Surgery 64.5
    Diagnosis
    Spondylolisthesis26
    Central Stenosis26
    Foraminal Stenosis14
    Post-laminectomy Syndrome Degenerative Scoliosis14 6
    Procedure 14 6
    1-Level64
    2-Level23
    3-Level3
    TLIF + LLIF Procedure3
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    Table 4

    MIS TLIF Subgroup Patient Based Outcome Data.

    Preoperative 1 Year Postoperative Paired t-test (p)
    ODI46.5 ± 15.2(n = 45)26.2 ± 20.4 (n = 40)0.0001
    VAS Back6.5 ± 15.5 (n = 45)3.2 ± 2.5 (n = 40)0.0001
    VAS Affected Leg5.4 ± 2.8 (n = 45)1.7 ± 2.8 (n = 40)0.0001
    Preoperative 6 Months Postoperative Paired t-test (p)
    SF-12 MCS41.3 ± 15.8 (n = 87)50.5 ± 12.7 (n = 34)0.05
    SF-12 PCS26.6 ± 10.7 (n = 87)39.9 ± 15.3 (n = 34)0.001
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International Journal of Spine Surgery
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1 Jan 2014
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Validation and Analysis of a Multi-site MIS Prospective Registry Through Sub-analysis of an MIS TLIF Subgroup
Joseph A. Sclafani, Kamshad Raiszadeh, Ramin Raiszadeh, Paul Kim, Todd Doerr, Farhan Siddiqi, Ivan LaMotta, Paul Park, Cary Templin, Sandeep Gill, Kevin Liang, Choll W. Kim
International Journal of Spine Surgery Jan 2014, 8 4; DOI: 10.14444/1004

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Validation and Analysis of a Multi-site MIS Prospective Registry Through Sub-analysis of an MIS TLIF Subgroup
Joseph A. Sclafani, Kamshad Raiszadeh, Ramin Raiszadeh, Paul Kim, Todd Doerr, Farhan Siddiqi, Ivan LaMotta, Paul Park, Cary Templin, Sandeep Gill, Kevin Liang, Choll W. Kim
International Journal of Spine Surgery Jan 2014, 8 4; DOI: 10.14444/1004
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Keywords

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  • MIS TLIF
  • Registry
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