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Research ArticleArticles

Perioperative Risks Associated with Cervical Spondylotic Myelopathy Based on Surgical Treatment Strategies

Angel Macagno, Shian Liu, Bryan J Marascalchi, Sun Yang, Anthony J Boniello, John A Bendo, Virginie C Lafage and Peter G Passias
International Journal of Spine Surgery January 2015, 9 24; DOI: https://doi.org/10.14444/2024
Angel Macagno
NY Spine Institute/NYU Medical Center-Hospital for Joint Diseases, New York City, NY
MD
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Shian Liu
NY Spine Institute/NYU Medical Center-Hospital for Joint Diseases, New York City, NY
BS
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Bryan J Marascalchi
NY Spine Institute/NYU Medical Center-Hospital for Joint Diseases, New York City, NY
MD
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Sun Yang
NY Spine Institute/NYU Medical Center-Hospital for Joint Diseases, New York City, NY
BA
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Anthony J Boniello
NY Spine Institute/NYU Medical Center-Hospital for Joint Diseases, New York City, NY
BS
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John A Bendo
NY Spine Institute/NYU Medical Center-Hospital for Joint Diseases, New York City, NY
MD
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Virginie C Lafage
NY Spine Institute/NYU Medical Center-Hospital for Joint Diseases, New York City, NY
PhD
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Peter G Passias
NY Spine Institute/NYU Medical Center-Hospital for Joint Diseases, New York City, NY
MD
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Article Figures & Data

Tables

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    Table 1

    Baseline demographics and hospital presentation amongst the four surgical approaches. All cohorts were statistically different from one another in every possible combination (p<0.0001), except the difference between the laminoplasty and combined cohorts for Deyo score was not statistically significant (p>0.05).

    AnteriorPosterior Decompression OnlyDecompression with Posterior FusionCombined APP-value
    Age57.563.463.059.6<0.0001
    LOS2.84.75.87.5<0.0001
    Deyo Score0.500.650.710.66<0.0001
    • View popup
    Table 2

    Baseline comorbidities amongst the four surgical approaches. The cohort with the largest percentage of complications is shaded.

    ComorbidityPercentage of AnteriorPercentage of Posterior Decompression Only LaminoplastyPercentage of Laminectom Decompression with Posterior FusionPercentage of Combined APp-value
    Anemia3.014.966.8810.70<0.0001
    Rheumatoid arthritis/collagen vascular diseases2.602.675.545.93<0.0001
    Chronic blood loss anemia0.130.340.400.88<0.0001
    Congestive heart failure1.973.483.783.27<0.0001
    Chronic pulmonary disease15.6516.5017.9018.31<0.0001
    Coagulopathy0.691.221.511.86<0.0001
    Diabetes16.9420.6321.6118.53<0.0001
    Hypertension46.9454.7157.8354.27<0.0001
    Liver disease0.500.790.860.75<0.0001
    Electrolyte imbalance3.136.359.0814.60<0.0001
    Neurological disorder3.704.975.215.48<0.0001
    Obesity7.426.796.977.21<0.0001
    Peripheral vascular disorders1.732.622.842.17<0.0001
    Pulmonary circulation disorders0.350.551.000.97<0.0001
    Renal failure1.763.113.593.89<0.0001
    Cardiac valvular disorder2.453.013.252.96<0.0001
    Pathologic weight loss0.540.811.302.30<0.0001
    • View popup
    Table 3

    Total procedure-related complication rate between the surgical approach groups.

    AnteriorPosterior Decompression OnlyDecompression with Posterior FusionCombined APP-value
    6.3%8.9%14.7%27.9%<0.0001
    • View popup
    Table 4

    Multivariate analysis of morbidity using the anterior cohort as the referent value adjusted for age, race, gender, Deyo score, and obesity.

    MorbidityOdds RatioLower CIUpper CIp-value
    Anterior----
    Posterior Decompression Only1.301.241.36<0.0001
    Decompression with Posterior Fusion2.192.112.28<0.0001
    Combined AP5.445.165.74<0.0001
    • View popup
    Table 5

    Complications amongst the four surgical approaches. The cohort with the largest percentage of complications is shaded.

    ComplicationPercentage of AnteriorPercentage of Posterior Decompression OnlyPercentage of Decompression with Posterior FusionPercentage of Combined APp Value
    Device-related 0.900.272.576.81 <0.0001
    Nervous System 0.450.820.901.46 <0.0001
    Cardiac 0.560.921.281.50 <0.0001
    Peripheral Vascular 0.030.100.060.09 <0.0001
    Respiratory 0.600.901.062.03 <0.0001
    Digestive System 0.300.360.410.62 <0.0001
    Urinary 0.561.411.401.02 <0.0001
    Post-op Shock 0.030.040.100.18 <0.0001
    Hematoma/ Seroma 0.810.651.251.72 <0.0001
    Puncture Vessel/ Nerve 0.560.920.921.59 <0.0001
    Wound Dehiscence 0.020.140.230.31 <0.0001
    Postoperative Infection 0.090.470.540.71 <0.0001
    Acute Post hemorrhagic Ane-mia 1.051.874.248.23 <0.0001
    Adult Respiratory Distress Syndrome 1.211.022.009.42 <0.0001
    Venous Thrombotic Events 0.280.420.800.84 <0.0001
    • View popup
    Table 6

    Comparing mortality rate among the surgical approach groups. *All cohorts were statistically different from one another in every possible combination (p<0.0001), except the difference between the anterior techniques and laminoplasty cohorts was not statistically significant (p>0.05).

    AnteriorPosterior Decompression OnlyDecompression with Posterior FusionCombined APP-value
    0.33%0.43%0.64%1.06%<0.0001
    • View popup
    Table 7

    Multivariate analysis of mortality using the anterior cohort as the referent value adjusted for age, race, gender, Deyo score, and obesity.

    MortalityOdds RatioLower CIUpper CIP-value
    Anterior----
    Posterior Decompression Only0.880.741.060.186
    Decompression with Posterior Fusion1.221.041.440.017
    Combined AP2.742.183.44<0.0001
    • View popup
    Table 8

    Limitations of Database--Nationwide Inpatient Sample from years 2001 to 2010.

    CategoryLimitation
    Disease Severity
    • Cannot indicate severity of pre-operative CSM

    • Cannot identify or weigh differently the variation in neurologic function

    • Nurick, Frankel, JOA, or Ducker Motor Index quantitative assessment of neurologic involvement unavailable

    • Presence or absence of myelomalacia is not controlled for

    Surgical Approach
    • Laminoplasty versus laminectomy differentiation using ICD-9-CM codes is difficult

    • NIS database does not list the presence nor the type of spinal instrumentation

    • NIS database pools together one-level surgeries with multi-level, including 5-level, operations.

    • The number of surgical vertebral levels has an impact on outcomes and it is expected that the combined anterior-posterior group has the highest number of multilevel cases.

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International Journal of Spine Surgery
Vol. 9
1 Jan 2015
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Perioperative Risks Associated with Cervical Spondylotic Myelopathy Based on Surgical Treatment Strategies
Angel Macagno, Shian Liu, Bryan J Marascalchi, Sun Yang, Anthony J Boniello, John A Bendo, Virginie C Lafage, Peter G Passias
International Journal of Spine Surgery Jan 2015, 9 24; DOI: 10.14444/2024

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Perioperative Risks Associated with Cervical Spondylotic Myelopathy Based on Surgical Treatment Strategies
Angel Macagno, Shian Liu, Bryan J Marascalchi, Sun Yang, Anthony J Boniello, John A Bendo, Virginie C Lafage, Peter G Passias
International Journal of Spine Surgery Jan 2015, 9 24; DOI: 10.14444/2024
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  • Article
    • Abstract
    • Introduction
    • Materials and Methods
    • Results
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    • Comorbidities
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Keywords

  • cervical spondylotic myelopathy
  • Anterior
  • combined
  • laminoplasty
  • laminectomy
  • procedure-related complications
  • nation-wide trends

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