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Research ArticleBiomechanics

Grb2 Expression in Acute Spinal Cord Injury After Methylprednisolone Intrathecal Injection in Rats

Yijun Zhou, Guanwen Sun, Changhong Li and Xiaoan Bai
International Journal of Spine Surgery October 2023, 8527; DOI: https://doi.org/10.14444/8527
Yijun Zhou
1 The First People’s Hospital of Changde, Changde Hospital Affiliated to Xiangya Medical College of Central South University, Hunan, People's Republic of China
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Guanwen Sun
1 The First People’s Hospital of Changde, Changde Hospital Affiliated to Xiangya Medical College of Central South University, Hunan, People's Republic of China
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Changhong Li
1 The First People’s Hospital of Changde, Changde Hospital Affiliated to Xiangya Medical College of Central South University, Hunan, People's Republic of China
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  • For correspondence: 9525569@qq.com 2032823295@qq.com
Xiaoan Bai
1 The First People’s Hospital of Changde, Changde Hospital Affiliated to Xiangya Medical College of Central South University, Hunan, People's Republic of China
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  • For correspondence: 9525569@qq.com 2032823295@qq.com
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    Figure

    Mean expression of Grb2 at each time point. Abbrevations: Grb2, growth factor receptor-bound protein 2; Mp, methylprednisolone.

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    Table 1

    Mean expression of Grb2 by group at each time point.

    ItemsTime After Injection
    0 h3 h8 h24 h
    Control group11.3451.5731.245
    Methylprednisolone group0.9960.9911.21.13
    • Abbreviations: Grb2, growth factor receptor-bound protein 2; iTRAQ, Isobaric tags for relative and absolute quantitation .

    • Note: iTRAQ have no specific values of expression of Grb2 in this study, so we assume C - 0 = 1.

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    Table 2

    iTRAQ ratios by group comparisons.

    Group ComparisonIsobaric Tags for Relative and Absolute Quantitation (iTRAQ) Ratio
    C-0 vs C-31.345
    C-0 vs C-81.573
    C-0 vs C-241.245
    C-0 vs MP-00.996
    C-3 vs MP-30.737
    C-8 vs MP-80.763
    C-24 vs MP-240.908
    • Abbreviations: C, control; MP, methylprednisolone.

    • Note: In the first column, the number represents the number of hours after injection.

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International Journal of Spine Surgery: 19 (S2)
International Journal of Spine Surgery
Vol. 19, Issue S2
1 Apr 2025
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Grb2 Expression in Acute Spinal Cord Injury After Methylprednisolone Intrathecal Injection in Rats
Yijun Zhou, Guanwen Sun, Changhong Li, Xiaoan Bai
International Journal of Spine Surgery Oct 2023, 8527; DOI: 10.14444/8527

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Grb2 Expression in Acute Spinal Cord Injury After Methylprednisolone Intrathecal Injection in Rats
Yijun Zhou, Guanwen Sun, Changhong Li, Xiaoan Bai
International Journal of Spine Surgery Oct 2023, 8527; DOI: 10.14444/8527
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Keywords

  • methylprednisolone
  • growth factor receptor-bound protein 2
  • acute spinal cord injury
  • isobaric tags for relative and absolute quantitation

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