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Research ArticleLumbar Spine

Predictability in Achieving Target Intervertebral Lordosis Using Personalized Interbody Implants

Saeed S. Sadrameli, Donald J. Blaskiewicz, Jahangir Asghar, Christopher P. Ames, Gregory M. Mundis, Joseph A. Osorio, Justin S. Smith, Chun-Po Yen, Sigurd H. Berven, Ashvin I. Patel, Michele Temple-Wong, Rodrigo J. Nicolau and Roland S. Kent
International Journal of Spine Surgery August 2024, 8637; DOI: https://doi.org/10.14444/8637
Saeed S. Sadrameli
1 AdventHealth Celebration, Celebration, FL, USA
MD
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  • For correspondence: Dr.Sadrameli@orlandoneurosurgery.com
Donald J. Blaskiewicz
2 St. Luke’s Boise Medical Center, Boise, ID, USA
MD
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Jahangir Asghar
3 Elite Spine Health and Wellness, Plantation, FL, USA
MD
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Christopher P. Ames
4 Department of Neurological Surgery, University of California, San Francisco, CA, USA
MD
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Gregory M. Mundis
5 Department of Orthopedic Surgery, Scripps Clinic, La Jolla, CA, USA
MD
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Joseph A. Osorio
6 Department of Neurological Surgery, University of California, San Diego, CA, USA
MD, PHD
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Justin S. Smith
7 Department of Neurosurgery, University of Virginia, Charlottesville, VA, USA
MD, PHD
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Chun-Po Yen
7 Department of Neurosurgery, University of Virginia, Charlottesville, VA, USA
MD
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Sigurd H. Berven
8 Department of Orthopedic Surgery, University of California, San Francisco, CA, USA
MD
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Ashvin I. Patel
9 Kennedy-White Orthopedic Center, Sarasota, FL, USA
MD
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Michele Temple-Wong
10 Carlsmed, Carlsbad, CA, USA
PHD
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Rodrigo J. Nicolau
10 Carlsmed, Carlsbad, CA, USA
MD
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Roland S. Kent
11 Axis Spine Center, Coeur d’Alene, ID, USA
MD
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  • Article
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  • Figure 1
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    Figure 1

    The focus of this study was on the intervertebral lordosis angle (IVL) as prescribed by the operating surgeon for the personalized device. It is defined as the angle between a tangent line to the upper (cranial) endplate of the lower vertebrae and a tangent line to the lower (caudal) endplate of the upper vertebrae.

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    Figure 2

    Example of vertebral endplate irregularity (left). Prevalence and distribution of endplate defects in the lumbar spine. Data presented are prevalence rates in percent, referring to the total samples studied for that specific disc level (right).24

  • Figure 3
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    Figure 3

    The fit of a stock interbody device against the endplate (left) is compared with the fit of a personalized device (right).

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    Figure 4

    Intervertebral lordosis (IVL) offset for all levels treated (A) and for levels treated with anterior lumbar interbody fusion (ALIF), lateral lumbar interbody fusion (LLIF), or transforaminal lumbar interbody fusion (TLIF) with personalized interbody implants (B).

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    Figure 5

    Distribution of the magnitude of the intervertebral lordosis (IVL) offset for all levels treated with personalized interbody implants of 217 adults who underwent spinal deformity surgery.

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    Figure 6

    Distribution of the magnitude of intervertebral lordosis (IVL) offset stratified by implant type.

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    Figure 7

    Distribution of intervertebral lordosis (IVL) offset stratified by implant type.

Tables

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    Table 1

    Demographic and pre- and postoperative radiographic parameters for the 217 adults with spinal deformity who received personalized interbody devices.

    VariablePreoperativePostoperative
    N 217NA
    Sex, women, n (%)128 (59)NA
    Age, y, mean (SD)66 (11)NA
    Radiographic Parameters
     Time since surgery, mo, median (min, max)NA17 (3, 38)
     LL, mean (SD)41.8° (17.3°)53.0° (28.3°)
     PI-LL mismatch, mean (SD)13.9° (16.8)4.0° (16.6°)
     IVL by level
     L1-L2, mean (SD)3.3° (3.1°)6.8° (2.6°)
     L2-L3, mean (SD)3.9° (3.7°)6.7° (3.4°)
     L3-L4, mean (SD)5.3° (3.6°)8.1° (2.9°)
     L4-L5, mean (SD)6.8° (5.3°)11.4° (4.7°)
     L5-S1, mean (SD)11.1° (7.0°)15.5° (4.8°)
    • Abbreviations: IVL, intervertebral lordosis angle; LL, lumbar lordosis; NA, not applicable; PI-LL, pelvic incidence and lumbar lordosis.

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    Table 2

    Operative parameters for the 217 adults in this study cohort.

    ParameterValue
    Levels fused, median (range)4 (1,16)
    Personalized interbody devices per subject, mean (SD, range)1.7 (0.8, 1–5)
    Patients with ALIF, n (%)99 (45.6)
    Patients with LLIF, n (%)53 (24.4)
    Patients with TLIF, n (%)80 (36.9)
    Personalized ALIF, n (% of total)145 (39.7)
     L3/L4, n (% of ALIF)9 (6.2)
     L4/L5, n (% of ALIF)46 (31.7)
     L5/S1, n (% of ALIF)90 (62.1)
    Personalized LLIF, n (% of total)99 (27.1)
     L1/L2, n (% of LLIF)15 (15.2)
     L2/L3, n (% of LLIF)38 (38.4)
     L3/L4, n (% of LLIF)29 (29.3)
     L4/L5, n (% of LLIF)17 (17.2)
    Personalized TLIF, n (% of total)121 (33.1)
     L1/L2, n (% of TLIF)3 (2.5)
     L2/L3, n (% of TLIF)1 (0.8)
     L3/L4, n (% of TLIF)12 (9.9)
     L4/L5, n (% of TLIF)50 (41.3)
     L5/S1, n (% of TLIF)55 (45.5)
    • Abbreviations: ALIF, anterior lumbar interbody fusion; LLIF, lateral lumbar interbody fusion; TLIF, transforaminal lumbar interbody fusion.

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International Journal of Spine Surgery: 19 (S2)
International Journal of Spine Surgery
Vol. 19, Issue S2
1 Apr 2025
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Predictability in Achieving Target Intervertebral Lordosis Using Personalized Interbody Implants
Saeed S. Sadrameli, Donald J. Blaskiewicz, Jahangir Asghar, Christopher P. Ames, Gregory M. Mundis, Joseph A. Osorio, Justin S. Smith, Chun-Po Yen, Sigurd H. Berven, Ashvin I. Patel, Michele Temple-Wong, Rodrigo J. Nicolau, Roland S. Kent
International Journal of Spine Surgery Aug 2024, 8637; DOI: 10.14444/8637

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Predictability in Achieving Target Intervertebral Lordosis Using Personalized Interbody Implants
Saeed S. Sadrameli, Donald J. Blaskiewicz, Jahangir Asghar, Christopher P. Ames, Gregory M. Mundis, Joseph A. Osorio, Justin S. Smith, Chun-Po Yen, Sigurd H. Berven, Ashvin I. Patel, Michele Temple-Wong, Rodrigo J. Nicolau, Roland S. Kent
International Journal of Spine Surgery Aug 2024, 8637; DOI: 10.14444/8637
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Keywords

  • intervertebral
  • lordosis
  • lumbar fusion
  • personalized
  • interbody
  • cage
  • device
  • pre-operative planning

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