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Research ArticleNew Technology

Repurposing Human Osteoarthritic Cartilage as a Bone Graft Substitute in an Athymic Rat Posterolateral Spinal Fusion Model

ALAN B.C. DANG, HELENA HONG, KATIE LEE, TAMMY LUAN, SANJAY REDDY and ALFRED C. KUO
International Journal of Spine Surgery December 2018, 12 (6) 735-742; DOI: https://doi.org/10.14444/5092
ALAN B.C. DANG
1Orthopaedic Section, Surgical Service, San Francisco VA Medical Center, San Francisco, California
2Department of Orthopaedic Surgery, University of California, San Francisco, California
MD
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HELENA HONG
3Washington University School of Medicine, St Louis, Missouri
BA
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KATIE LEE
2Department of Orthopaedic Surgery, University of California, San Francisco, California
BA
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TAMMY LUAN
1Orthopaedic Section, Surgical Service, San Francisco VA Medical Center, San Francisco, California
BA
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SANJAY REDDY
1Orthopaedic Section, Surgical Service, San Francisco VA Medical Center, San Francisco, California
MS
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ALFRED C. KUO
1Orthopaedic Section, Surgical Service, San Francisco VA Medical Center, San Francisco, California
2Department of Orthopaedic Surgery, University of California, San Francisco, California
MD, PHD
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    Figure 1

    Experimental outline.

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    Figure 2

    Micro–computed tomography images showing time course of single-level posterolateral lumbar spinal fusion using hypertrophic chondrocyte pellet grafts in a single animal. (a, b) In vivo immediately after implantation. (c, d) In vivo 4 weeks postoperatively. (e, f) Ex vivo 8 weeks postoperatively.

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    Figure 3

    Radiographic and histologic appearance of remnant cartilage grafts at 8 weeks. Micro–computed tomography (a), safranin-O staining (b, d), and Masson trichrome staining (c, e) of fusion masses show spherical areas of unmineralized cartilaginous tissue.

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    Figure 4

    Maturation of fusion masses. From 4 to 8 weeks, the amount of cartilage in the fusion masses decreased and mean bone mineral density increased. There was a trend toward increased bone volume with time; however, this did not reach statistical significance.

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International Journal of Spine Surgery
Vol. 12, Issue 6
1 Dec 2018
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Repurposing Human Osteoarthritic Cartilage as a Bone Graft Substitute in an Athymic Rat Posterolateral Spinal Fusion Model
ALAN B.C. DANG, HELENA HONG, KATIE LEE, TAMMY LUAN, SANJAY REDDY, ALFRED C. KUO
International Journal of Spine Surgery Dec 2018, 12 (6) 735-742; DOI: 10.14444/5092

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Repurposing Human Osteoarthritic Cartilage as a Bone Graft Substitute in an Athymic Rat Posterolateral Spinal Fusion Model
ALAN B.C. DANG, HELENA HONG, KATIE LEE, TAMMY LUAN, SANJAY REDDY, ALFRED C. KUO
International Journal of Spine Surgery Dec 2018, 12 (6) 735-742; DOI: 10.14444/5092
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Keywords

  • endochondral bone formation
  • spinal fusion
  • animal models

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