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Research ArticleComplications

Disseminated Intravascular Coagulation in Pediatric Scoliosis Surgery: A Systematic Review

Sarah E. Walker, Lee Bloom, Patrick J. Mixa, Karen Paltoo, Frank S. Cautela, Hiram Luigi-Martinez, Joseph P. Scollan, Zhida Jin, Bhaveen H. Kapadia, Andrew Yang, Allison B. Spitzer, Peter G. Passias, Virginie Lafage, Khalid Hesham, Carl B. Paulino and Bassel G. Diebo
International Journal of Spine Surgery February 2022, 16 (1) 4-10; DOI: https://doi.org/10.14444/8201
Sarah E. Walker
1 Orthopaedic Surgery, State University of New York, Downstate Medical Center, Brooklyn, NY, USA
MD
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Lee Bloom
1 Orthopaedic Surgery, State University of New York, Downstate Medical Center, Brooklyn, NY, USA
MD
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Patrick J. Mixa
1 Orthopaedic Surgery, State University of New York, Downstate Medical Center, Brooklyn, NY, USA
MD
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Karen Paltoo
1 Orthopaedic Surgery, State University of New York, Downstate Medical Center, Brooklyn, NY, USA
MD
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Frank S. Cautela
1 Orthopaedic Surgery, State University of New York, Downstate Medical Center, Brooklyn, NY, USA
MD
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Hiram Luigi-Martinez
1 Orthopaedic Surgery, State University of New York, Downstate Medical Center, Brooklyn, NY, USA
MD
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Joseph P. Scollan
1 Orthopaedic Surgery, State University of New York, Downstate Medical Center, Brooklyn, NY, USA
MD
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Zhida Jin
1 Orthopaedic Surgery, State University of New York, Downstate Medical Center, Brooklyn, NY, USA
MD
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Bhaveen H. Kapadia
1 Orthopaedic Surgery, State University of New York, Downstate Medical Center, Brooklyn, NY, USA
MD
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Andrew Yang
1 Orthopaedic Surgery, State University of New York, Downstate Medical Center, Brooklyn, NY, USA
MD
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Allison B. Spitzer
1 Orthopaedic Surgery, State University of New York, Downstate Medical Center, Brooklyn, NY, USA
MD
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Peter G. Passias
2 NY Spine Institute/Division of Spine Surgery, NYU Langone Medical Center, New York, NY, USA
MD
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Virginie Lafage
3 Orthopaedic Surgery, Lenox Hill/Northwell Health, New York, NY, USA
PhD
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Khalid Hesham
1 Orthopaedic Surgery, State University of New York, Downstate Medical Center, Brooklyn, NY, USA
MD
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Carl B. Paulino
1 Orthopaedic Surgery, State University of New York, Downstate Medical Center, Brooklyn, NY, USA
MD
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Bassel G. Diebo
1 Orthopaedic Surgery, State University of New York, Downstate Medical Center, Brooklyn, NY, USA
4 Orthopaedic Surgery, Warren Alpert Medical School of Brown University, Providence, RI, USA
MD
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    Figure

    Flow diagram outlining the systematic review performed for this study.

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    Table 1

    Intraoperative and postoperative information for patients with disseminated intravascular coagulopathy following scoliosis surgery.

    Study NamePast MedicalHistoryTime of DestabilizationIO ComplicationPO SymptomsPO Diagnosis/Intervention
    Benavides S et al, 2003Viral illness prior to PO blood donationIOFever, hypotensionSeptic shock, ARDS, LE ischemia, seizures, hypotension, renal failure, anemia Yersinia enterocolitica from transfusion, BL below knee amputation, multiple intracranial hemorrhagic infarcts with subsequent seizure disorder
    Canbay O et al, 2004NRPODislocation of a pedicular pin at T3, loss of LE motor function, hypotension, myoclonic spasmsHypotension, tachycardia and fever, myoclonic spasms, malignant hyperthermiaMyelography with nonionic, water-soluble contrast, rhabdomyolysis
    Chechik O et al, 2010Cerebral palsyPONRNRNR
    Ferschl M et al, 2009NoneIOVentricular tachycardia, ventricular fibrillation, cardiac arrest, surgical site bleeding, hypotension, cardiac resuscitationHypotension, ventricular fibrillationIO application of a (20 mL) topical hemostatic matrix for increased bleeding at L2 pedicle was sent into intravascular space
    Gabos PG et al, 2012.Rett syndromePONRNRHeparin-induced thrombocytopenia following right leg deep vein thrombosis treatment
    Hassmann GC et al, 1974Distal weaknessIOPulseless ventricular tachycardia (at 90th min), cardiac massage performed, increased bleedingHypotension, restrictive lung disease, petechiae, hematuriaCoagulopathy after homologous blood
    Master DL et al, 2011NonePOCoagulopathy, excessive blood loss, cardiac failure, deathNRDeath
    McKie JS et al, 1997NoneIOIncreased bleeding, hypotensionHypotension, ST- segment depression, ARDS, acute pancreatitisCoagulopathy after reinfusion of IO retrieved blood
    Murray DJ el al, 1992Cerebral palsy with spastic quadriparesisIOIncreased bleedingNRCoagulopathy after reinfusion of IO retrieved blood
    Murray DJ el al, 1992Myelomeningocele, T10 sensory levelIOIncreased bleeding, hematuriaNRCoagulopathy after reinfusion of IO retrieved blood
    Ogura Y et al, 2011Cavernous hemangiomaPOMassive hemorrhage from hemangioma, hypotensionAgitation, hypovolemic shock, BL frontal and temporal ischemia, aphasiaPO hemorrhage from hemangioma. Aphasia resolved and infarcts decreased in size
    Raphael BG et al, 1982Paraplegia, T6 injury at birthIOIncreased bleeding, hypotension24 h PO bleedingUnknown
    Raphael BG et al, 1982Familial osteochondromatosisIOIncreased bleeding24 h PO bleedingUnknown
    • ARDS, acute respiratory distress syndrome; BL, bilateral; IO, intraoperative; LE, lower extremity; NR, not recorded; PO, postoperative.

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    Table 2

    A summary of patient demographics, scoliosis type, procedure performed, and labs taken during time of disseminated intravascular coagulopathy.

    Study NameAgeSexScoliosis TypeProcedurePlatelets (109 /L)Prothrombin Time (s)Fibrin Degradation Products (s)Fibrinogen (mg/dL)
    Benavides S et al, 200312FCongenitalPosterior spinal fusionNRNRNRNR
    Canbay O et al, 200414FCongenitalPosterior spinal fusionNRNR>15075
    Chechik O et al, 2010NRNRNeuromuscularPosterior spinal fusionNRNRNRNR
    Ferschl M et al, 200918FIdiopathicPosterior spinal fusion11NR>10051
    Gabos PG et al, 201214FNeuromuscularUnit rodNR17.450NR
    Hassmann GC et al, 197413FNeuromuscularHarrington rod7518.850130
    Master DL et al, 2011NRNRNeuromuscularPosterior spinal fusionNRNRNRNR
    McKie JS et al, 199717MIdiopathicHarrington rodNR17.4>150NR
    Murray DJ et al, 199218MNeuromuscularPosterior spinal fusion95NRNRNR
    Murray DJ et al, 199217FNeuromuscularPosterior spinal fusion46187550
    Ogura Y et al, 201112MTumor inducedPosterior spinal fusion192015019
    Raphael BG et al, 198226FNeuromuscularDistraction rods73.516.456125
    Raphael BG et al, 198213FTumor inducedHarrington distraction rod751751.270
    • NR, not reported.

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International Journal of Spine Surgery
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1 Feb 2022
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Disseminated Intravascular Coagulation in Pediatric Scoliosis Surgery: A Systematic Review
Sarah E. Walker, Lee Bloom, Patrick J. Mixa, Karen Paltoo, Frank S. Cautela, Hiram Luigi-Martinez, Joseph P. Scollan, Zhida Jin, Bhaveen H. Kapadia, Andrew Yang, Allison B. Spitzer, Peter G. Passias, Virginie Lafage, Khalid Hesham, Carl B. Paulino, Bassel G. Diebo
International Journal of Spine Surgery Feb 2022, 16 (1) 4-10; DOI: 10.14444/8201

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Disseminated Intravascular Coagulation in Pediatric Scoliosis Surgery: A Systematic Review
Sarah E. Walker, Lee Bloom, Patrick J. Mixa, Karen Paltoo, Frank S. Cautela, Hiram Luigi-Martinez, Joseph P. Scollan, Zhida Jin, Bhaveen H. Kapadia, Andrew Yang, Allison B. Spitzer, Peter G. Passias, Virginie Lafage, Khalid Hesham, Carl B. Paulino, Bassel G. Diebo
International Journal of Spine Surgery Feb 2022, 16 (1) 4-10; DOI: 10.14444/8201
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Keywords

  • disseminated intravascular coagulation
  • scoliosis
  • pediatric surgery
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