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Research ArticleCervical Spine

Cervical Deformity Correction Fails to Achieve Age-Adjusted Spinopelvic Alignment Targets

Peter G. Passias, Katherine E. Pierce, Samantha R. Horn, Anand Segar, Lara Passfall, Nicholas Kummer, Oscar Krol, Cole Bortz, Avery E. Brown, Haddy Alas, Frank A. Segreto, Waleed Ahmad, Sara Naessig, Aaron J. Buckland, Themistocles S. Protopsaltis, Michael Gerling, Renaud Lafage, Frank J. Schwab and Virginie Lafage
International Journal of Spine Surgery June 2022, 16 (3) 450-457; DOI: https://doi.org/10.14444/8260
Peter G. Passias
1 Departments of Orthopaedic and Neurologic Surgery, NYU Langone Orthopedic Hospital; New York Spine Institute, New York, NY, USA
MD
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Katherine E. Pierce
1 Departments of Orthopaedic and Neurologic Surgery, NYU Langone Orthopedic Hospital; New York Spine Institute, New York, NY, USA
BS
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Samantha R. Horn
1 Departments of Orthopaedic and Neurologic Surgery, NYU Langone Orthopedic Hospital; New York Spine Institute, New York, NY, USA
BA
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Anand Segar
2 Department of Orthopaedics, NYU Langone Orthopedic Hospital, New York, NY, USA
MD
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Lara Passfall
1 Departments of Orthopaedic and Neurologic Surgery, NYU Langone Orthopedic Hospital; New York Spine Institute, New York, NY, USA
BS
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Nicholas Kummer
1 Departments of Orthopaedic and Neurologic Surgery, NYU Langone Orthopedic Hospital; New York Spine Institute, New York, NY, USA
BS
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Oscar Krol
1 Departments of Orthopaedic and Neurologic Surgery, NYU Langone Orthopedic Hospital; New York Spine Institute, New York, NY, USA
BA
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Cole Bortz
1 Departments of Orthopaedic and Neurologic Surgery, NYU Langone Orthopedic Hospital; New York Spine Institute, New York, NY, USA
BA
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Avery E. Brown
1 Departments of Orthopaedic and Neurologic Surgery, NYU Langone Orthopedic Hospital; New York Spine Institute, New York, NY, USA
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Haddy Alas
1 Departments of Orthopaedic and Neurologic Surgery, NYU Langone Orthopedic Hospital; New York Spine Institute, New York, NY, USA
MD
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Frank A. Segreto
1 Departments of Orthopaedic and Neurologic Surgery, NYU Langone Orthopedic Hospital; New York Spine Institute, New York, NY, USA
BS
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Waleed Ahmad
1 Departments of Orthopaedic and Neurologic Surgery, NYU Langone Orthopedic Hospital; New York Spine Institute, New York, NY, USA
MS
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Sara Naessig
1 Departments of Orthopaedic and Neurologic Surgery, NYU Langone Orthopedic Hospital; New York Spine Institute, New York, NY, USA
BS
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Aaron J. Buckland
2 Department of Orthopaedics, NYU Langone Orthopedic Hospital, New York, NY, USA
MBBS
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Themistocles S. Protopsaltis
2 Department of Orthopaedics, NYU Langone Orthopedic Hospital, New York, NY, USA
MD
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Michael Gerling
2 Department of Orthopaedics, NYU Langone Orthopedic Hospital, New York, NY, USA
MD
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Renaud Lafage
3 Department of Orthopaedic Surgery, Hospital for Special Surgery, New York, NY, USA
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Frank J. Schwab
3 Department of Orthopaedic Surgery, Hospital for Special Surgery, New York, NY, USA
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Virginie Lafage
3 Department of Orthopaedic Surgery, Hospital for Special Surgery, New York, NY, USA
PhD
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    Figure

    Schematic of the measured sagittal alignment parameters for the cervical and global spinopelvic spinal regions. cSVA, cervical sagittal vertical axis; CL, cervical lordosis; CBVA, chin-brow vertical angle; TK, thoracic kyphosis; LL, lumbar lordosis; SVA, sagittal vertical axis; PT, pelvic tilt; PI, pelvic incidence.

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    Table 1

    Alignment values measured preoperatively for spinopelvic and lower extremity alignment parameters across increasing patient age groups.

    Actual Postoperative AlignmentAge Group P
    <40 y40–65 y≥65 y
    Spinopelvic
     Sagittal vertical axis (mm)−14 ± 15.6−1.2 ± 48.316.8 ± 46.8 0.050
     Pelvic tilt (°)7.8 ± 4.815.7 ± 9.124.3 ± 9.5 <0.001
     Pelvic Incidence minus lumbar lordosis (°)−9.2 ± 9.8−3.5 ± 11.95.7 ± 14.2 0.002
     Lumbar lordosis and thoracic kyphosis (°)22.1 ± 14.515.4 ± 13.4−1 ± 22 <0.001
    Lower extremity
     Sacrofemoral angle (°)205.5 ± 12.7199.3 ± 9.4198.3 ± 11.40.312
     Knee angle (°)0.06 ± 4.23.7 ± 6.21.3 ± 5.70.743
     Ankle angle (°)4.5 ± 2.36.6 ± 3.15.5 ± 2.90.858
     Pelvic shift (mm)20 ± 23.521.6 ± 30.315.3 ± 36.50.617
    • Note: Boldface indicates statistical significance.

    • View popup
    Table 2

    Alignment values measured preoperatively vs 1 y postoperatively for spinopelvic and cervical alignment parameters within the entire cervical deformity cohort.

    Radiographic MeasurePreoperative1 y P
    Pelvic tilt (°)1616.80.323
    Pelvic incidence and lumbar lordosis (°)−3.1−1.1 0.034
    T4-T12 (°)−43.1−420.367
    T1SS (°)2931.50.062
    T1 slope minus cervical lordosis (°)25.923.90.335
    C2-C7 (°)37.7 0.024*
    Cervical sagittal vertical angle (mm)26.327.70.290
    C2-T3 (°)0.743.10.357
    SVA C2-T3 (°)51.455.9 0.026*
    C2SS (°)22.7200.245
    SVA (mm)2.58.80.142
    • Note: Boldface indicates statistical significance.

    • C2SS, C2 sacral slope; SVA, sagittal vertical axis; T1SS, T1 sacral slope.

    • View popup
    Table 3

    Measured 1 y postoperative (ACTUAL) and age-adjusted (IDEAL) values for sagittal global and spinopelvic alignment parameters for age cohorts.

    AgeGroup, yMean Age, ySagittal Vertical Axis (mm)Pelvic Tilt (°)Pelvic Incidence-Lumbar Lordosis (°)Lumbar Lordosis-Thoracic Kyphosis (°)
    ACTUALIDEALACTUALIDEALACTUALIDEALACTUALIDEAL
    <4024.9 ± 6.61.7 ± 20.5−12.9 ± 97.5 ± 413.7 ± 1.5−8 ± 6.4−6.5 ± 2.323.7 ± 16.35.5 ± 2.3
    0.181 0.010 0.499 0.022
    40–6555.9 ± 6.94 ± 46.417.6 ± 1715.7 ± 818.8 ± 2.1−3.4 ± 121.2 ± 3.113.8 ± 1813.2 ± 3.1
    0.045 0.002 0.004 0.801
    ≥6574.1 ± 6.027.5 ± 45.460.9 ± 1125.5 ± 11.726 ± 1.88.9 ± 1412 ± 2.7−0.47 ± 25.424 ± 2.7
    0.005 0.8460.311 <0.001
    • Note: Boldface indicates statistical significance (P < 0.05).

    • View popup
    Table 4

    Measured 1 y postoperative (ACTUAL) and age-adjusted (IDEAL) values for sagittal global and spinopelvic alignment parameters for entire cohort.

    Radiographic MeasureACTUALIDEAL P
    Pelvic tilt (°)17.120.1 0.001
    Mismatch between pelvic incidence and lumbar lordosis (°)−1.83.1 <0.001
    Sagittal vertical axis (mm)1.925.3 <0.001
    Mismatch between lumbar lordosis and thoracic kyphosis (°)12.115.10.177
    • Note: Boldface indicates statistical significance (P < 0.0).

    • View popup
    Table 5

    Percentages of patients within each age cohort and overall who matched age-adjusted ideals (MATCH), those that undercorrected (UNDER) and those that overcorrected (OVER), based upon a ±10-y interval of age-adjusted values calculated with Renaud et al’s established formulas.Differences in lower extremity compensatory mechanisms (SFA, KA, AA, PS, GSA) by age group.

    Age Adjustment IdealsUNDERUnder OverallMATCHMatch OverallOVEROver Overall
    Pelvic tilt (°)
     <40 y0%24.40%28.6%24.40%71.4%51.10%
     40–65 y19.4%27%53.2%
     ≥65 y47.6%14.3%38.1%
    Mismatch between pelvic tilt-lumbar lordosis (°)
     <40 y25%23.00%0%27.60%75%49.40%
     40–65 y22.6%27.4%50%
     ≥65 y23.8%33.3%42.9%
    Sagittal vertical axis (mm)
     <40 y42.9%18.80%57.1%40.00%0%41.30%
     40–65 y18.5%40.7%40.7%
     ≥65 y10.5%31.6%57.9%
    Mismatch between lumbar lordosis and thoracic kyphosis (°)
     <40 y85.7%42.90%14.3%18.70%0%38.50%
     40–65 y46.0%25.4%28.6%
     ≥65 y19%0%81%
    • View popup
    Table 6

    Differences in lower extremity compensatory mechanisms (SFA, KA, AA, PS, GSA) by age group.

    Compensatory Mechanism and Age Group, yPre- to Postoperative Change P
    TK
     <40–1.80.410
     40–65–0.790.502
     ≥65–2.00.676
    SFA
     <405.50.075
     40–656.50.275
     ≥65–2.30.088
    KA
     <40–2.50.264
     40–655.40.275
     ≥65–0.120.931
    AA
     <40–0.440.757
     40–651.140.002a
     ≥65–0.740.241
    PS
     <40–6.40.517
     40–65–4.90.149
     ≥656.50.521
    GSA
     <40–0.480.004a
     40–65–2.80.224
     ≥650.370.629
    • ↵a Statistically significant.

    • AA, ankle angle; CD, cervical deformity; GSA, global sagittal angle; KA, knee angle; PS, pelvic shift; SFA, sacrofemoral angle; TK, thoracic kyphosis.

    • View popup
    Table 7

    Pre- to Postoperative differences in lower extremity compensatory mechanisms (SFA, KA, AA, PS, GSA) for overall, worsened (increase in TS-CL and cSVA), and improved (decrease in TS-CL and cSVA) CD cohorts.

    Compensatory Mechanism and CohortPreoperativePostoperative P
    TK
     Overall–42.1–430.535
     Worsen–41.1–45.30.106
     Improve–42.7–41.40.415
    SFA
     Overall199.6195.60.286
     Worsen197.5196.40.225
     Improve199.8194.60.36
    KA
     Overall2.7–10.27
     Worsen3.12.80.691
     Improve2.6–2.40.33
    AA
     Overall6.15.50.036a
     Worsen5.95.40.161
     Improve6.15.60.19
    PS
     Overall20.921.90.742
     Worsen22.723.10.921
     Improve21.924.70.55
    GSA
     Overall12.80.261
     Worsen0.7910.593
     Improve1.240.258
    • ↵a Statistically significant.

    • AA, ankle angle; CD, cervical deformity; cSVA, cervical sagittal vertical angle; GSA, global sagittal angle; KA, knee angle; PS, pelvic shift; SFA, sacrofemoral angle; TK, thoracic kyphosis; TS-CL, T1 slope minus cervical lordosis.

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Cervical Deformity Correction Fails to Achieve Age-Adjusted Spinopelvic Alignment Targets
Peter G. Passias, Katherine E. Pierce, Samantha R. Horn, Anand Segar, Lara Passfall, Nicholas Kummer, Oscar Krol, Cole Bortz, Avery E. Brown, Haddy Alas, Frank A. Segreto, Waleed Ahmad, Sara Naessig, Aaron J. Buckland, Themistocles S. Protopsaltis, Michael Gerling, Renaud Lafage, Frank J. Schwab, Virginie Lafage
International Journal of Spine Surgery Jun 2022, 16 (3) 450-457; DOI: 10.14444/8260

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Cervical Deformity Correction Fails to Achieve Age-Adjusted Spinopelvic Alignment Targets
Peter G. Passias, Katherine E. Pierce, Samantha R. Horn, Anand Segar, Lara Passfall, Nicholas Kummer, Oscar Krol, Cole Bortz, Avery E. Brown, Haddy Alas, Frank A. Segreto, Waleed Ahmad, Sara Naessig, Aaron J. Buckland, Themistocles S. Protopsaltis, Michael Gerling, Renaud Lafage, Frank J. Schwab, Virginie Lafage
International Journal of Spine Surgery Jun 2022, 16 (3) 450-457; DOI: 10.14444/8260
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