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Research ArticleComplications

Does a Reported Penicillin Allergy Affect Outcomes Following Elective Posterior Lumbar Fusions?

Austin J. Roebke, Azeem T. Malik, Safdar N. Khan and Elizabeth Yu
International Journal of Spine Surgery December 2022, 16 (6) 1023-1028; DOI: https://doi.org/10.14444/8326
Austin J. Roebke
1 Department of Orthopaedics, The Ohio State University Wexner Medical Center, Columbus, OH, USA
MD
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Azeem T. Malik
1 Department of Orthopaedics, The Ohio State University Wexner Medical Center, Columbus, OH, USA
MD
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Safdar N. Khan
1 Department of Orthopaedics, The Ohio State University Wexner Medical Center, Columbus, OH, USA
MD
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Elizabeth Yu
1 Department of Orthopaedics, The Ohio State University Wexner Medical Center, Columbus, OH, USA
MD
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  • For correspondence: Elizabeth.Yu@osumc.edu
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    Table 1

    Baseline demographics of the study population.

    DemographicsPatient-Reported Penicillin Allergy (n = 7497)No Penicillin Allergy (n = 278,545) P Value
    Age, y0.410
     <651662 (22.2%)63,023 (22.6%)
     65–692025 (27.0%)76,403 (27.4%)
     70–741751 (23.4%)63,639 (22.8%)
     75–791233 (16.4%)44,822 (16.1%)
     80–84598 (8.0%)21,402 (7.7%)
     ≥85164 (2.2%)6355 (2.3%)
    Gender<0.001
     Male2041 (27.2%)105,212 (37.8%)
     Female5392 (71.9%)170,432 (61.2%)
     Unknown64 (0.9%)2901 (1.0%)
    Region<0.001
     Midwest1463 (19.5%)72,523 (26.0%)
     Northeast792 (10.6%)36,314 (13.0%)
     South3673 (49.0%)122,287 (43.9%)
     West1567 (20.9%)47,406 (17.0%)
     Unknown2 (<0.1%)15 (<0.1%)
    Elixhauser Comorbidity Index, mean ± SD4.9 ± 2.04.7 ± 2.0<0.001
    • Note: Data presented as n (%) unless otherwise noted.

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    Table 2

    Ninety-day outcomes between PA and non-PA patient populations.

    FactorPA, n (%)No PA, n (%)OR (95% CI) P Value
    Surgical site infections288 (3.8%)8695 (3.1%)1.20 (1.07–1.36) 0.002
    Urinary tract infections924 (12.3%)27,968 (10.0%)1.16 (1.08–1.24) <0.001
    Sepsis109 (1.5%)3253 (1.2%)1.24 (1.02–1.50) 0.026
    Acute kidney injury283 (3.8%)8931 (3.2%)1.19 (1.05–1.34) 0.006
    Pneumonia185 (2.5%)6919 (2.5%)0.99 (0.85–1.14)0.853
    All-cause readmissions735 (9.8%)23,696 (8.5%)1.15 (1.07–1.25) <0.001
    • Abbreviation: PA, penicillin allergy.

    • Note: Boldface indicates statistically significant findings.

    • View popup
    Table 3

    Inpatient charges and reimbursements between PA and non-PA patient populations.

    FactorPA, Mean ± SDNo PA, Mean ± SDRisk-Adjusted Marginal Cost (Ref: No PA) P Value
    Inpatient charges$87,565 ± $53,290$81,385 ± $51,222+$4340 (SE: 583) <0.001
    Inpatient reimbursements$22,891 ± $8931$21,587 ± $8827$1221 (SE: 100) <0.001
    • Abbreviations: PA, penicillin allergy; SE, standard error.

    • Note: Boldface indicates statistically significant findings.

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Does a Reported Penicillin Allergy Affect Outcomes Following Elective Posterior Lumbar Fusions?
Austin J. Roebke, Azeem T. Malik, Safdar N. Khan, Elizabeth Yu
International Journal of Spine Surgery Dec 2022, 16 (6) 1023-1028; DOI: 10.14444/8326

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Does a Reported Penicillin Allergy Affect Outcomes Following Elective Posterior Lumbar Fusions?
Austin J. Roebke, Azeem T. Malik, Safdar N. Khan, Elizabeth Yu
International Journal of Spine Surgery Dec 2022, 16 (6) 1023-1028; DOI: 10.14444/8326
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