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Research ArticleLumbar Spine

Impact of Postoperative Length of Stay on Patient-Reported and Clinical Outcomes After Anterior Lumbar Interbody Fusion

Madhav R. Patel, Kevin C. Jacob, Frank A. Chavez, Alexander W. Parsons, Meenakshi Seetharaman, Hanna Pawlowski, Michael C. Prabhu, Nisheka N. Vanjani and Kern Singh
International Journal of Spine Surgery April 2023, 17 (2) 205-214; DOI: https://doi.org/10.14444/8414
Madhav R. Patel
1 Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, IL, USA
BS
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Kevin C. Jacob
1 Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, IL, USA
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Frank A. Chavez
1 Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, IL, USA
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Alexander W. Parsons
1 Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, IL, USA
MS
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Meenakshi Seetharaman
1 Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, IL, USA
BS
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Hanna Pawlowski
1 Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, IL, USA
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Michael C. Prabhu
1 Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, IL, USA
BS
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Nisheka N. Vanjani
1 Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, IL, USA
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Kern Singh
1 Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, IL, USA
MD
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Article Figures & Data

Tables

    • View popup
    Table 1

    Patient demographics.

    CharacteristicLOS ≥45 h
    (n = 52)
    LOS <45 h
    (n = 52)
    P Valuea
    Age, y, mean ± SD50.3 ± 11.650.6 ± 12.50.880
    Gender0.844
     Women48.1% (25)50.0% (26)
     Men51.9% (27)50.0% (26)
    Ethnicity0.566
     African American11.5% (6)7.7% (4)
     Asian3.9% (2)3.9% (2)
     Hispanic5.8% (3)9.6% (5)
     White75.0% (39)78.9% (41)
     Other3.9% (2)0.0% (0)
    Diabetic status0.085
     Nondiabetic80.8% (42)92.3% (48)
     Diabetic19.2% (10)7.7% (4)
    Smoking status0.446
     Nonsmoker84.6% (44)78.9% (41)
     Smoker15.4% (8)21.2% (11)
    Blood pressure0.083
     Normotensive63.5% (33)78.9% (41)
     Hypertensive36.5% (19)21.2% (11)
    American Society of Anesthesiologists score0.356
     <18.0% (4)13.7% (7)
     ≥192.0% (46)86.3% (44)
    Charlson Comorbidity Index score0.848
     <120.5% (9)22.2% (8)
     ≥179.6% (35)77.8% (28)
    Insurance type0.624
     Medicare/Medicaid7.7% (4)7.7% (4)
     Workers’ compensation25.0% (13)17.3% (9)
     Private67.3% (35)75.0% (39)
    • Note: Data reported as % (n) unless otherwise noted.

    • ↵a P value calculated using χ 2 analysis or Student’s t test for independent samples for categorical and continuous variables, respectively.

    • LOS, length of stay.

    • View popup
    Table 2

    Perioperative characteristics.

    CharacteristicLOS ≥45 h
    (n = 52)
    LOS <45 h
    (n = 52)
    P Valuea
    Spinal pathology
     Degenerative spondylolisthesis23.1% (12)9.6% (5)0.063
     Isthmic spondylolisthesis36.5% (19)50.0% (26)0.166
     Recurrent herniated nucleus pulposus5.8% (3)7.7% (4)0.696
     Scoliosis1.9% (1)11.5% (6)0.050
     Central stenosis73.1% (38)80.8% (42)0.352
     Foraminal stenosis40.4% (21)69.2% (36) 0.003
    Operative time, min126.3 ± 37.4128.1 ± 40.10.816
    Estimated blood loss, mL73.5 ± 50.252.1 ± 31.1 0.014
    LOS (h)65.1 ± 29.926.8 ± 7.6 <0.001
    Day of discharge <0.001
     POD 00.0% (0)9.6% (5)
     POD 12.1% (1)82.7% (43)
     POD 266.0% (31)7.7% (4)
     POD 314.9% (7)0.0% (0)
     POD 414.9% (7)0.0% (0)
     POD 92.1% (1)0.0% (0)
    • Note: Data presented as % (n) or mean ± SD. Boldface indicates statistical significance.

    • ↵a P value calculated using χ 2 analysis or Student’s t test for independent samples for categorical and continuous variables, respectively.

    • LOS, length of stay; POD, postoperative day of discharge.

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    Table 3

    Impact of LOS on PROMs.

    PROMLOS ≥45 h,
    Mean ± SD
    LOS <45 h,
    Mean ± SD
    P Valuea
    VAS back
     Preoperative6.5 ± 2.36.7 ± 2.60.673
     6 wk4.3 ± 2.73.8 ± 2.50.257
     12 wk4.0 ± 2.63.3 ± 2.60.212
     6 mo3.0 ± 2.63.4 ± 2.80.511
     1 y3.0 ± 3.52.1 ± 3.00.657
     2 y8.5 ± 0.06.4 ± 1.60.377
    VAS leg
     Preoperative5.1 ± 2.74.5 ± 3.40.813
     6 wk4.5 ± 4.33.3 ± 2.40.263
     12 wk3.2 ± 2.82.5 ± 2.60.662
     6 mo2.0 ± 2.62.6 ± 3.10.613
     1 y2.2 ± 3.71.1 ± 1.70.489
     2 y6.5 ± 0.06.3 ± 2.60.964
    ODI
     Preoperative39.4 ± 17.535.7 ± 15.80.477
     6 wk45.1 ± 32.528.3 ± 14.8 0.024
     12 wk29.3 ± 16.120.3 ± 12.40.082
     6 mo22.3 ± 20.220.2 ± 15.80.739
     1 y30.5 ± 24.214.9 ± 16.20.153
     2 y40.0 ± 0.028.5 ± 13.70.507
    SF-12 PCS
     Preoperative27.1 ± 6.332.6 ± 9.5 0.046
     6 wk34.0 ± 11.834.8 ± 8.40.838
     12 wk32.2 ± 5.141.5 ± 8.7 0.014
     6 mo40.3 ± 8.140.0 ± 9.50.920
     1 y37.6 ± 9.145.9 ± 11.00.193
     2 y36.2 ± 2.544.6 ± 11.80.271
    PROMIS-PF
     Preoperative34.4 ± 5.038.4 ± 5.80.072
     6 wk40.8 ± 2.640.0 ± 5.90.847
     12 wk40.2 ± 4.644.6 ± 9.20.271
     6 mo43.0 ± 7.247.2 ± 6.50.199
     1 y44.0 ± 9.148.7 ± 11.00.411
     2 y47.2 ± 9.049.6 ± 12.20.823
    • Note: Boldface indicates statistical significance.

    • ↵a P values calculated using Student’s t test for independent samples.

    • LOS, length of stay; ODI, Oswestry Disability Index; PROMIS-PF, patient-reported outcome measurement information system physical function; PROMs, patient-reported outcome measures; SF-12 PCS, 12-item short form physical composite score; VAS, visual analog scale.

    • View popup
    Table 4

    Minimum clinically important difference.

    Patient-Reported Outcome MeasuresLOS ≥45 h,
    % (n)
    LOS <45 h,
    % (n)
    P Valuea
    ODI
     6 wk28.6% (2)71.4% (5)0.703
     12 wk10.0% (1)90.0% (9)0.375
     6 mo37.5% (3)62.5% (5)0.561
     1 y14.3% (1)85.7% (6)0.515
     2 y0.0% (0)0.0% (0)-
     Overall17.7% (3)82.4% (14) 0.004
    PROMIS-PF
     6 wk9.1% (1)90.9% (10)0.747
     12 wk22.2% (2)77.8% (7)0.964
     6 mo16.7% (2)83.3% (10)0.137
     1 y22.2% (2)77.8% (7)0.480
     2 y33.3% (1)66.7% (2)1.000
     Overall18.2% (4)81.8% (18) 0.001
    SF-12 PCS
     6 wk25.0% (3)75.0% (9)0.527
     12 wk14.3% (2)85.7% (12)0.490
     6 mo32.3% (6)64.7% (11)0.394
     1 y11.1% (1)88.9% (8)0.522
     2 y25.0% (1)75.0% (3)0.809
     Overall24.1% (7)75.9% (22) 0.001
    VAS back
     6 wk44.0% (22)56.0% (28)0.201
     12 wk47.1% (24)52.9% (27)0.566
     6 mo51.1% (23)48.9% (22)0.222
     1 y22.2% (2)77.8% (7)0.913
     2 y0.0% (0)100.0% (1)0.505
     Overall43.7% (31)56.3% (40)0.058
    VAS leg
     6 wk31.3% (5)68.8% (11)0.312
     12 wk18.8% (3)81.3% (13)0.925
     6 mo33.3% (5)66.7% (10)0.637
     1 y25.0% (2)75.0% (6)0.707
     2 y100.0% (1)100.0% (1)-
     Overall27.6% (8)72.4% (21) 0.004
    • Note: Boldface indicates statistical significance.

    • ↵a P values calculated using χ 2 analysis.

    • LOS, length of stay; ODI, Oswestry Disability Index; PROMIS-PF, patient-reported outcome measurement information system physical function; SF-12 PCS, 12-item short form physical composite score; VAS, visual analog scale.

    • View popup
    Table 5

    Complication rates.

    ComplicationLOS
    <45 h
    (n = 52)
    LOS
    ≥45 h
    (n = 52)
    P Valuea
    Urinary retention1.9% (1)15.7% (8) 0.016
    Urinary tract infection0.0% (0)0.0% (0)-
    Acute respiratory failure0.0% (0)0.0% (0)-
    Acute renal failure0.0% (0)0.0% (0)-
    Ileus0.0% (0)0.0% (0)-
    Deep vein thrombosis0.0% (0)0.0% (0)-
    Transfusion0.0% (0)0.0% (0)-
    Arrhythmia0.0% (0)2.0% (1)0.496
    Pneumonia0.0% (0)0.0% (0)-
    Pneumothorax0.0% (0)0.0% (0)-
    Altered mental status0.0% (0)0.0% (0)-
    Durotomy0.0% (0)0.0% (0)-
    Surgical site infection0.0% (0)0.0% (0)-
    Neurological disease1.9% (1)1.9% (1)-
    Fever0.0% (0)15.7% (8) 0.003
    Total complications3.9% (2)28.9% (15) 0.001
    • Note: Boldface indicates statistical significance.

    • ↵a P value calculated using Fisher’s exact test.

    • LOS, length of stay (h).

    • View popup
    Table 6

    Bivariate analysis of risk ratio for demographic and perioperative characteristics.

    CharacteristicAmong Extended Length of Stays, %Relative RiskCI P Valuea
    Age
     <50 y42.3%Reference
     ≥50 y57.7%1.1(0.8–1.7)0.559
    Gender
     Women48.1%Reference
     Men51.9%1.0(0.7–1.5)0.845
    Body mass index
     <30 kg/m2 53.9%Reference
     ≥30 kg/m2 46.2%0.9(0.6–1.4)0.697
    Smoking status
     Nonsmoker84.6%Reference
     Smoker15.4%0.8(0.5–1.4)0.476
    American Society of Anesthesiologists score
     <2 71.2% Reference
     ≥2 28.9% 1.7 (1.2–2.4) 0.003
    Charlson Comorbidity Index score
     <120.5%Reference
     ≥179.6%1.0(0.6–1.7)0.851
    Hypertension
     Nonhypertensive63.5%Reference
     Hypertensive36.5%1.4(1.0–2.1)0.066
    Diabetes
     Nondiabetic 80.8% Reference
     Diabetic 19.2% 1.5 (1.0–2.3) 0.037
    Preoperative VAS backb
     <7----
     ≥7----
    Preoperative VAS leg
     <7 17.3% Reference
     ≥7 82.7% 2.1 (1.2–3.8) 0.012
    Operative time
     ≤127 min44.2%Reference
     >127 min55.8%1.1(0.8–1.7)0.560
    Estimated blood loss
     ≤63 mL57.7%Reference
     >63 mL42.3%1.2(0.8–1.7)0.415
    • Note: Boldface indicates statistical significance.

    • ↵a P value calculated using Poisson’s regression.

    • ↵b Unable to perform Poisson’s regression due to collinearity.

    • VAS, visual analog scale.

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International Journal of Spine Surgery
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Impact of Postoperative Length of Stay on Patient-Reported and Clinical Outcomes After Anterior Lumbar Interbody Fusion
Madhav R. Patel, Kevin C. Jacob, Frank A. Chavez, Alexander W. Parsons, Meenakshi Seetharaman, Hanna Pawlowski, Michael C. Prabhu, Nisheka N. Vanjani, Kern Singh
International Journal of Spine Surgery Apr 2023, 17 (2) 205-214; DOI: 10.14444/8414

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Impact of Postoperative Length of Stay on Patient-Reported and Clinical Outcomes After Anterior Lumbar Interbody Fusion
Madhav R. Patel, Kevin C. Jacob, Frank A. Chavez, Alexander W. Parsons, Meenakshi Seetharaman, Hanna Pawlowski, Michael C. Prabhu, Nisheka N. Vanjani, Kern Singh
International Journal of Spine Surgery Apr 2023, 17 (2) 205-214; DOI: 10.14444/8414
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