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Research ArticleNUCLEUS REPLACEMENT
Open Access

Screening for Nuclear Replacement Candidates in Patients With Lumbar Degenerative Disc Disease

Ioannis Pappou, Frank Cammisa, Elias Papadopoulos, Peter Frelinghuysen and Federico Girardi
International Journal of Spine Surgery January 2008, 2 (2) 114-119; DOI: https://doi.org/10.1016/SASJ-2007-0116-RR
Ioannis Pappou
Hospital for Special Surgery, New York, New York
MD
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Frank Cammisa Jr.
Hospital for Special Surgery, New York, New York
MD
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Elias Papadopoulos
Hospital for Special Surgery, New York, New York
MD
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Peter Frelinghuysen
Hospital for Special Surgery, New York, New York
MD
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Federico Girardi
Hospital for Special Surgery, New York, New York
MD
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  • Article
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Figures

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  • Figure 1
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    Figure 1

    Disc height measurements at the anterior, mid- and posterior portion on lateral radiographs at the L4/5 disc. A) radiograph B) drawing (Note that the L5-S1 segment is >50% collapsed in comparison to the adjacent L4-5).

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    Figure 2

    Appearance of a symptomatic L5-S1 segment with >50% collapse on plain radiographs (A) and MRI (B). Adjacent segment is healthy on MRI (grade 2) and was therefore used as reference.

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    Figure 3
  • Figure 4
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    Figure 4

    CT-discogram demonstrating (A) a severely degenerated disc/annulus, with a tear extending through all fibers and large annular deficiency (>50%) - unsuitable for PDN implantation, (B) a complete but focal tear (<10% of annular periphery) -suitable for PDN implantation, and (C) an incomplete, focal tear- suitable for PDN implantation.

Tables

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    Table 1

    Absolute and Relative Frequencies of Affected Levels

    LevelFrequency%
    L2-321.7
    L3-41613.7
    L4-54437.6
    L5-S15547.0
    Total117
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    Table 2

    Classification of Disc Degeneration by Pfirrmann et al.

    GradeStructure and AnulusDistinction of NucleusSignal Intensity Intervertebral DiscHeight of
    IHomogeneous, bright whiteClearHyperintense, isotense to cerebrospinal fluidNormal
    IIInhomogeneous with or without horizontal bandsClearHyperintense, isotense to cerebrospinal fluidNormal
    IIIInhomogeneous, grayUnclearIntermediateNormal to slightly decreased
    IVInhomogeneous, gray to blackLostIntermediate to hypointenseNormal to moderately decreased
    VInhomogeneous, blackLostHypointenseCollapsed disc space
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    Table 3

    Dallas Classification of Disc Degeneration on CT-Discograms

    Degeneration (Annulus)Annular disruption (Contrast Extension)
    0 - No change0 - None
    1 - Local (<10%)1 - Into inner annulus
    2 - Partial (<50%)2 - Into outer annulus
    3 -Total (>50%)3 -Beyond outer annulus
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    Table 4

    Summary of the Levels Serially Eliminated Due to Rapidiographic and Clinincal Contraindications to Nuclear Replacement

    LevelStartSchmorl>50% CollapseIrregular EndplatesInsufficient EnnulusNo Radiographic Contraindictions%BMI> 30Overall Suitable for Nuclear Replacement%
    L2-32000021001150
    L3-41610041168.83850
    L4-54421183272.762659.1
    L5-S15511010201425.521221.8
    Totals 11741111325950.4124740.2
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    Table 5

    Overall Prevalence of Contraindications to Nuclear Replacement at Each Affected Level

    LevelStartSchmorl>50% CollapseIrregular EndplatesInsufficient AnnulusBMI > 30
    L2-3200001
    L3-41610043
    L4-544212139
    L5-S15511015348
    Totals 117411175121
    %3.49.414.543.617.9
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International Journal of Spine Surgery
Vol. 2, Issue 2
1 Jan 2008
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Screening for Nuclear Replacement Candidates in Patients With Lumbar Degenerative Disc Disease
Ioannis Pappou, Frank Cammisa, Elias Papadopoulos, Peter Frelinghuysen, Federico Girardi
International Journal of Spine Surgery Jan 2008, 2 (2) 114-119; DOI: 10.1016/SASJ-2007-0116-RR

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Screening for Nuclear Replacement Candidates in Patients With Lumbar Degenerative Disc Disease
Ioannis Pappou, Frank Cammisa, Elias Papadopoulos, Peter Frelinghuysen, Federico Girardi
International Journal of Spine Surgery Jan 2008, 2 (2) 114-119; DOI: 10.1016/SASJ-2007-0116-RR
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Keywords

  • prosthetic disc nucleus
  • degenerative disc disease
  • contraindications
  • indications
  • nuclear replacement

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