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Research ArticleBASIC SCIENCE
Open Access

Evaluation of Perivascular Adhesion Formation in New Zealand White Rabbits Using Oxiplex and DuraSeal Xact Adhesion Barrier System

Fred Mo, James Yue, Jianghui Zhang, Kreg Howk and Allister Williams
International Journal of Spine Surgery January 2009, 3 (2) 68-76; DOI: https://doi.org/10.1016/SASJ-2009-0006-NT
Fred Mo
aDepartment of Orthopaedics and Rehabilitation, Yale University School of Medicine
MD
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James Yue
aDepartment of Orthopaedics and Rehabilitation, Yale University School of Medicine
MD
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Jianghui Zhang
aDepartment of Orthopaedics and Rehabilitation, Yale University School of Medicine
MD
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Kreg Howk
bCovidien
MS
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Allister Williams
aDepartment of Orthopaedics and Rehabilitation, Yale University School of Medicine
MD
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  • Article
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Article Figures & Data

Figures

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  • Figures 1A & 1B
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    Figures 1A & 1B

    Dissection through skin and subcutaneous tissue. Identification of major vessels is indicated by the black rectangle.

  • Figures 2A & 2B
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    Figures 2A & 2B

    Figures 2A and 2B. (A) DSX is supplied as a kit with blue and clear precursor solutions and a mixing device. (B) It is prepared and applied simultaneously using the applicator.

  • Figures 3A & 3B
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    Figures 3A & 3B

    DSX in situ. (A) Vessel before DSX application. (B) Vessel after DSX application. The application site is precisely identified by the blue color.

  • Figures 4A & 4B
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    Figures 4A & 4B

    Necropsy images. (A) In the untreated control group, major vessels were surrounded by adhesions. (B) In the DSX group, adhesions in the treatment area were minimal, enabling easy mobilization and identification of anatomic structures.

  • Figure 5
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    Figure 5

    The extent of adhesion in the DSX group was significantly less than in the control group (mean of 1.3 vs 2.5, P ≤ .05). The scores for OX were not significantly different from controls and varied widely.

  • Figure 6
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    Figure 6

    The severity of adhesions in the DSX group was significantly less than in the control group (mean of 1.25 vs 2.8, P ≤ .05). The scores for OX were not significantly different from controls and varied widely.

  • Figure 1
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    Figure 1

    Complications arising from anterior lumbar fusions vs. refusions.

Tables

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    Table 1

    Incidence of dural tears in various operations in the MedPar database (Age 65 or over, United States).

    Operation%
    Refusion of lumbar and lumbosacral spine, posterior technique7.3%
    Posterior dorsal and dorsolumbar fusion6.8%
    Refusion of lumbar and lumbosacral spine, anterior technique6.8%
    Refusion of dorsal and dorsolumbar spine, posterior technique6.6%
    Re-open laminectomy site6.0%
    Posterior lumbar fusion5.8%
    Anterior lumbar fusion5.7%
    Refusion of lumbar spine, lateral transverse process technique5.4%
    Anterior dorsal and dorsolumbar fusion5.4%
    Decompression of the spinal canal5.2%
    Lateral lumbar fusion4.5%
    Discectomy3.5%
    Refusion of other cervical spine, posterior technique2.3%
    Spine fusion, nos1.7%
    Atlas-axis spine fusion1.5%
    Repair of vertebral fracture1.4%
    Posterior cervical fusion1.3%
    Refusion of other cervical spine, anterior technique1.2%
    Anterior cervical fusion0.5%
    Refusion of dorsal and dorsolumbar spine, anterior technique0.0%
    • Source: PearlDiver data derived from HIPAA-compliant insurance and private payer sources. These tables and charts are for information purposes only. The PearlDiver data has been obtained or derived from sources believed by PearlDiver to be reliable, but PearlDiver Technologies Inc. does not represent that the information is 100% accurate or complete. Any opinions or estimates which form any portion of the tables, charts or other aspects of this report represent the judgment of PearlDiver's analysts and management and are subject to change without notice. Copyright © 2009 PearlDiver Technologies Inc.

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International Journal of Spine Surgery
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1 Jan 2009
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Evaluation of Perivascular Adhesion Formation in New Zealand White Rabbits Using Oxiplex and DuraSeal Xact Adhesion Barrier System
Fred Mo, James Yue, Jianghui Zhang, Kreg Howk, Allister Williams
International Journal of Spine Surgery Jan 2009, 3 (2) 68-76; DOI: 10.1016/SASJ-2009-0006-NT

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Evaluation of Perivascular Adhesion Formation in New Zealand White Rabbits Using Oxiplex and DuraSeal Xact Adhesion Barrier System
Fred Mo, James Yue, Jianghui Zhang, Kreg Howk, Allister Williams
International Journal of Spine Surgery Jan 2009, 3 (2) 68-76; DOI: 10.1016/SASJ-2009-0006-NT
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Keywords

  • Perivascular adhesions
  • DuraSeal Xact
  • PEG hydrogel
  • Oxiplex
  • surgical sealant
  • adhesion barrier

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